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DC Field | Value | Language |
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dc.contributor.author | Alves Souza, Rodrigo Wagner | - |
dc.contributor.author | Aguiar, Andreo F. | - |
dc.contributor.author | Vechetti-Junior, Ivan J. | - |
dc.contributor.author | Piedade, Warlen Pereira | - |
dc.contributor.author | Rocha Campos, Gerson Eduardo | - |
dc.contributor.author | Dal-Pai-Silva, Maeli | - |
dc.date.accessioned | 2015-03-18T15:56:07Z | - |
dc.date.accessioned | 2016-10-25T20:35:19Z | - |
dc.date.available | 2015-03-18T15:56:07Z | - |
dc.date.available | 2016-10-25T20:35:19Z | - |
dc.date.issued | 2014-08-01 | - |
dc.identifier | http://dx.doi.org/10.1519/JSC.0000000000000421 | - |
dc.identifier.citation | Journal Of Strength And Conditioning Research. Philadelphia: Lippincott Williams & Wilkins, v. 28, n. 8, p. 2338-2345, 2014. | - |
dc.identifier.issn | 1064-8011 | - |
dc.identifier.uri | http://hdl.handle.net/11449/117425 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/117425 | - |
dc.description.abstract | The aim of this study was to investigate the effects of a resistance training program with excessive training load and insufficient recovery time between bouts on muscle hypertrophy-and atrophy-related protein expression. Male Wistar rats were randomly assigned to either a trained (TR, N = 9) or a sedentary (SE, N = 9) group. The TR group was subjected to a 12-week resistance training program with excessive training load and insufficient recovery between bouts that was designed to induce plantaris muscle atrophy. After the 12-week experiment, the plantaris muscle was collected to analyze the cross-sectional area (CSA) of the muscle fibers, and MAFbx, MyoD, myogenin, and IGF-I protein expression (Western blot). The CSA was reduced significantly (-17%, p <= 0.05) in the TR group compared with the SE group. Reciprocally, there was a significant (p <= 0.05) 20% increase in MAFbx protein expression, whereas the MyoD (-27%), myogenin (-29%), and IGF-I (-43%) protein levels decreased significantly (p <= 0.05) in the TR group compared with the SE group. In conclusion, our data indicated that muscle atrophy induced by resistance training with excessive training load and insufficient recovery was associated with upregulation of the MAFbx catabolic protein and downregulation of the MyoD, myogenin, and IGF-I anabolic proteins. These findings suggest that quantitative analysis of these proteins can be important and complementary with other biochemical markers to confirm a possible overtraining diagnosis. | en |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | - |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | - |
dc.format.extent | 2338-2345 | - |
dc.language.iso | eng | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.source | Web of Science | - |
dc.subject | overworked muscles | en |
dc.subject | muscle atrophy | en |
dc.subject | MAFbx | en |
dc.subject | MyoD | en |
dc.subject | myogenin | en |
dc.subject | IGF-I | en |
dc.title | Resistance training with excessive training load and insufficient recovery alters skeletal muscle mass-related protein expression | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | North Univ Parana UNOPAR | - |
dc.contributor.institution | Universidade Estadual de Campinas (UNICAMP) | - |
dc.description.affiliation | Sao Paulo State Univ UNESP, Dept Morphol, Sao Paulo, Brazil | - |
dc.description.affiliation | North Univ Parana UNOPAR, Ctr Biol & Hlth Sci, Londrina, Parana, Brazil | - |
dc.description.affiliation | Univ Estadual Campinas, Dept Anat Cell Biol Physiol & Biophys, Sao Paulo, Brazil | - |
dc.description.affiliationUnesp | Sao Paulo State Univ UNESP, Dept Morphol, Sao Paulo, Brazil | - |
dc.description.sponsorshipId | FAPESP: 08/52641-1 | - |
dc.description.sponsorshipId | CNPq: 130628/2008-5 | - |
dc.identifier.doi | 10.1519/JSC.0000000000000421 | - |
dc.identifier.wos | WOS:000340206400031 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Journal Of Strength And Conditioning Research | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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