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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/117437
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dc.contributor.authorOshiro Junior, Joao Augusto-
dc.contributor.authorShiota, Leticia Moriya-
dc.contributor.authorChiavacci, Leila Aparecida-
dc.date.accessioned2015-03-18T15:56:08Z-
dc.date.accessioned2016-10-25T20:35:21Z-
dc.date.available2015-03-18T15:56:08Z-
dc.date.available2016-10-25T20:35:21Z-
dc.date.issued2014-01-01-
dc.identifierhttp://dx.doi.org/10.1590/S1517-70762014000100005-
dc.identifier.citationMateria-rio De Janeiro. Rio De Janeiro Rj: Univ Fed Rio De Janeiro, Lab Hidrogenio, v. 19, n. 1, p. 24-32, 2014.-
dc.identifier.issn1517-7076-
dc.identifier.urihttp://hdl.handle.net/11449/117437-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/117437-
dc.description.abstractFilm forming polymeric systems represents a new and unexplored technology of systems forskin or wounds protection and for controlled drug release. The aim of this work was to study the use of polymeric organic-inorganic ureasil-polyether hybrids synthesized by the sol-gel process as film forming system containing silver sulfadiazine as model drug. The film formationtime can be controlled by changing the precursor/catalyst ratio used during the step of hydrolysis and condensations. The results showed that the precursor/catalyst proportion influences both the visual characteristics and time required to form the film. The precursor/catalyst ratio equal to 20.8 m/v was considered ideal due to promote the homogeneous and transparent film formation in less than 5 minutes. The release profile of sulfadiazine is dependent on the characteristics of the matrixes: matrix more hydrophobic as ureasil-POP provided a slowed released mainly due to the low swelling of the matrix. The more hydrophilic ureasil-POE matrix presents a large capacity to swell and favors the faster release of the drug. The set of results showed the possibility of future use of these systems for treating wounds caused by burns.en
dc.format.extent24-32-
dc.language.isopor-
dc.publisherUniv Fed Rio De Janeiro, Lab Hidrogenio-
dc.sourceWeb of Science-
dc.subjectHybrid materialen
dc.subjectfilm forming systemen
dc.subjecttreatment of burnsen
dc.subjectsulfadiazine silveren
dc.titleDevelopment of organic-inorganic polymeric film formers for controlled drug release and wound careen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias Farmaceut Araraquara, Dept Farmacos & Medicamentos, BR-14801902 Araraquara, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias Farmaceut Araraquara, Dept Farmacos & Medicamentos, BR-14801902 Araraquara, SP, Brazil-
dc.identifier.doi10.1590/S1517-70762014000100005-
dc.identifier.wosWOS:000340432700005-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofMateria-rio De Janeiro-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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