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DC Field | Value | Language |
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dc.contributor.author | Espirito Santo, Rafael D. do | - |
dc.contributor.author | Machado, Marcella G. M. | - |
dc.contributor.author | Santos, Jean Leandro dos | - |
dc.contributor.author | Gonzalez, Eduardo R. P. | - |
dc.contributor.author | Chin, Chung Man | - |
dc.date.accessioned | 2015-03-18T15:56:12Z | - |
dc.date.accessioned | 2016-10-25T20:35:24Z | - |
dc.date.available | 2015-03-18T15:56:12Z | - |
dc.date.available | 2016-10-25T20:35:24Z | - |
dc.date.issued | 2014-01-01 | - |
dc.identifier | http://dx.doi.org/10.2174/138527281820141028104429 | - |
dc.identifier.citation | Current Organic Chemistry. Sharjah: Bentham Science Publ Ltd, v. 18, n. 20, p. 2572-2602, 2014. | - |
dc.identifier.issn | 1385-2728 | - |
dc.identifier.uri | http://hdl.handle.net/11449/117457 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/117457 | - |
dc.description.abstract | Over one billion people worldwide are afflicted by a group of 17 infectious diseases, known as the neglected tropical diseases (NTDs), reaching mainly undeveloped countries that suffer with a lack of economic incentive, research and policy for new drug discovery. Compounds with guanidine moiety are privileged structures and are attractive as scaffold for the discovery of new drug candidates. This functional group is an important pharmacophore moiety in several therapeutically active compounds. Guanidine-containing heterocycles have been reported to exhibit different biological properties including antiprotozoal and antiparasitic activity such as mebendazole and pyrimethamine used in current therapeutics. The present review covers the progress of guanidine derivatives for NTDs (Human African Trypanosomiasis, Chagas Disease, Leishmaniasis, Buruli Ulcer, Echinococcosis, Taeniasis/Cysticercosis, Lymphatic Filariasis and Onchocerciasis). Also, review the development of new guanidine derivatives in Malaria and Tuberculosis. | en |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | - |
dc.description.sponsorship | Post-graduation Program POSMAT | - |
dc.description.sponsorship | Post-graduation Program Pharmaceutical Sciences at University of Sao Paulo State, UNESP | - |
dc.format.extent | 2572-2602 | - |
dc.language.iso | eng | - |
dc.publisher | Bentham Science Publ Ltd | - |
dc.source | Web of Science | - |
dc.subject | Antiparasitic | en |
dc.subject | antiprotozoal | en |
dc.subject | guanidine derivatives | en |
dc.subject | guanidine | en |
dc.subject | neglected tropical diseases | en |
dc.title | Use of Guanidine Compounds in the Treatment of Neglected Tropical Diseases | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | Univ Sao Paulo State, UNESP, Fac Sci & Technol, Dept Phys Chem & Biol, BR-19060900 Presidente Prudente, SP, Brazil | - |
dc.description.affiliation | Univ Sao Paulo State, UNESP, Postgrad Program Sci & Tecnol Mat POSMAT, BR-19060900 Presidente Prudente, SP, Brazil | - |
dc.description.affiliation | Univ Sao Paulo State, UNESP, Sch Pharmaceut Sci, Lapdesf Lab Drug Design,Dept Drugs & Med, BR-14801902 Araraquara, SP, Brazil | - |
dc.description.affiliation | Univ Sao Paulo State, UNESP, Postgrad Program Pharmaceut Sci, BR-19060900 Presidente Prudente, SP, Brazil | - |
dc.description.affiliationUnesp | Univ Sao Paulo State, UNESP, Fac Sci & Technol, Dept Phys Chem & Biol, BR-19060900 Presidente Prudente, SP, Brazil | - |
dc.description.affiliationUnesp | Univ Sao Paulo State, UNESP, Postgrad Program Sci & Tecnol Mat POSMAT, BR-19060900 Presidente Prudente, SP, Brazil | - |
dc.description.affiliationUnesp | Univ Sao Paulo State, UNESP, Sch Pharmaceut Sci, Lapdesf Lab Drug Design,Dept Drugs & Med, BR-14801902 Araraquara, SP, Brazil | - |
dc.description.affiliationUnesp | Univ Sao Paulo State, UNESP, Postgrad Program Pharmaceut Sci, BR-19060900 Presidente Prudente, SP, Brazil | - |
dc.identifier.doi | 10.2174/138527281820141028104429 | - |
dc.identifier.wos | WOS:000344610200002 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Current Organic Chemistry | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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