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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/117458
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dc.contributor.authorNascimento, Carla Manuela Crispim-
dc.contributor.authorPereira, Jessica Rodrigues-
dc.contributor.authorAndrade, Larissa Pires de-
dc.contributor.authorGaruffi, Marcelo-
dc.contributor.authorTalib, Leda Leme-
dc.contributor.authorForlenza, Orestes Vicente-
dc.contributor.authorMaria Cancela, Jose-
dc.contributor.authorCominetti, Marcia Regina-
dc.contributor.authorStella, Florindo-
dc.date.accessioned2015-03-18T15:56:12Z-
dc.date.accessioned2016-10-25T20:35:24Z-
dc.date.available2015-03-18T15:56:12Z-
dc.date.available2016-10-25T20:35:24Z-
dc.date.issued2014-01-01-
dc.identifierhttp://dx.doi.org/10.2174/156720501108140910122849-
dc.identifier.citationCurrent Alzheimer Research. Sharjah: Bentham Science Publ Ltd, v. 11, n. 8, p. 799-805, 2014.-
dc.identifier.issn1567-2050-
dc.identifier.urihttp://hdl.handle.net/11449/117458-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/117458-
dc.description.abstractThe benefits of physical exercise to reduce low-grade inflammation and improve Brain-Derived Neurotrophic Factor (BDNF) levels and cognitive function became a growing field of interest. Low-grade inflammation is common during aging and seems to be linked to neurodegenerative process. Regular physical exercises can help to reduce pro-inflammatory cytokines levels and to improve BDNF peripheral concentrations. The main goal of this research was to analyze the effects of a 16-week multimodal physical exercise program on peripheral BDNF levels and on Tumor Necrosis-alpha (TNF-alpha) and Interleukin-6 (IL-6) as pro-inflammatory markers in cognitive healthy elderly individuals and in elderly with mild cognitive impairment (MCI). Cognitive functions were assessed by the Montreal Cognitive Assessment (MoCA) prior to and after the intervention. Thirty cognitively healthy participants and thirty-seven MCI participants were assigned to the control (CG) and trained (TG) groups. The TG participated in a multimodal physical training program for a 16-week period. The results showed a significant between-subjects interaction, which indicates the beneficial contribution of training on the reduction of TNF-alpha (p= 0.001) and IL-6 (p<0.001) and on the improvement of BDNF (p<0.001) peripheral concentrations. Cognitive functions also presented significant improvements for MCI trained group (p= 0.03). In conclusion, physical exercise was effective to reduce pro-inflammatory cytokines and to improve BDNF peripheral levels, with positive reflexes on cognition. To the best of our knowledge, this is the first study that evaluated longitudinally the effects of a multimodal physical exercises protocol on peripheral concentrations of pro-inflammatory cytokines and cognition performance in elderly MCI individuals.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.format.extent799-805-
dc.language.isoeng-
dc.publisherBentham Science Publ Ltd-
dc.sourceWeb of Science-
dc.subjectAgingen
dc.subjectcognitionen
dc.subjectinflammationen
dc.subjectinterleukin-6en
dc.subjectmild cognitive impairmenten
dc.subjectphysical activityen
dc.subjecttumor necrosis factor alphaen
dc.titlePhysical Exercise in MCI Elderly Promotes Reduction of Pro-Inflammatory Cytokines and Improvements on Cognition and BDNF Peripheral Levelsen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniv Vigo-
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)-
dc.description.affiliationUNESP Univ Estadual Paulista, Dept Educ Fis, Lab Envelhecimento & Atividade Fis LAFE, BR-13506900 Rio Claro, SP, Brazil-
dc.description.affiliationUniv Sao Paulo, Fac Med, Dept Psiquiatria, BR-01060970 Sao Paulo, Brazil-
dc.description.affiliationUniv Sao Paulo, Fac Med, Inst Psiquiatria, Lab Neurociencias LIM 27, BR-01060970 Sao Paulo, Brazil-
dc.description.affiliationUniv Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, BR-01060970 Sao Paulo, Brazil-
dc.description.affiliationUniv Vigo, HealthyFyt Grp, Fac Ciencias Deporte, Vigo 36310, Spain-
dc.description.affiliationUniv Fed Sao Carlos, Dept Gerontol, Lab Biol Envelhecimento LABEN, BR-13565905 Sao Carlos, SP, Brazil-
dc.description.affiliationUNESP Univ Estadual Paulista, Inst Biociencias, BR-13506900 Sao Paulo, Brazil-
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Dept Educ Fis, Lab Envelhecimento & Atividade Fis LAFE, BR-13506900 Rio Claro, SP, Brazil-
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Inst Biociencias, BR-13506900 Sao Paulo, Brazil-
dc.description.sponsorshipIdFAPESP: 02/13633-7-
dc.identifier.doi10.2174/156720501108140910122849-
dc.identifier.wosWOS:000342142600009-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofCurrent Alzheimer Research-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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