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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/117554
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dc.contributor.authorFreitas, P. C.-
dc.contributor.authorCarvalho-Salles, A. B.-
dc.contributor.authorMendiburu, C. F.-
dc.contributor.authorRicci, O.-
dc.contributor.authorFett-Conte, A. C.-
dc.date.accessioned2015-03-18T15:56:25Z-
dc.date.accessioned2016-10-25T20:35:38Z-
dc.date.available2015-03-18T15:56:25Z-
dc.date.available2016-10-25T20:35:38Z-
dc.date.issued2011-01-01-
dc.identifierhttp://dx.doi.org/10.4238/2011.November.4.5-
dc.identifier.citationGenetics And Molecular Research. Ribeirao Preto: Funpec-editora, v. 10, n. 4, p. 2718-2720, 2011.-
dc.identifier.issn1676-5680-
dc.identifier.urihttp://hdl.handle.net/11449/117554-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/117554-
dc.description.abstractThis study reports on a cytogenetic finding in a bone marrow examination of a 47-year-old male patient treated in the Hematology and Blood Transfusion Service of the Hospital de Base in Sao Jose do Rio Preto, Sao Paulo State, Brazil. The only alteration found at diagnosis of myelodysplastic syndrome (MDS) subtype refractory anemia with excess blasts (RAEB-2) was clonal monosomy of chromosome 21. The patient evolved to acute myeloid leukemia type M2 and died nine months after diagnosis. Clonal monosomy of chromosome 21, as the only cytogenetic abnormality in MDS, has only been reported three times previously. This uncommon cytogenetic abnormality in MDS has been associated with a poor clinical course, although more data will be needed to determine if this prognosis is invariable.en
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.format.extent2718-2720-
dc.language.isoeng-
dc.publisherFunpec-editora-
dc.sourceWeb of Science-
dc.subjectMyelodysplastic syndromeen
dc.subjectMonosomy 21en
dc.subjectClonal chromosomal abnormalitiesen
dc.titleClonal monosomy of chromosome 21 in a case of myelodysplastic syndromeen
dc.typeoutro-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationEscola Med Sao Jose do Rio Preto, Dept Biol Mol, Sao Jose Do Rio Preto, SP, Brazil-
dc.description.affiliationUniv Estadual Sao Paulo Julio de Mesquita Filho, Inst Biociencias Letras & Ciencias Exatas, Dept Biol, Sao Jose Do Rio Preto, SP, Brazil-
dc.description.affiliationEscola Med Sao Jose do Rio Preto, Dept Med 2, Sao Jose Do Rio Preto, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Sao Paulo Julio de Mesquita Filho, Inst Biociencias Letras & Ciencias Exatas, Dept Biol, Sao Jose Do Rio Preto, SP, Brazil-
dc.identifier.doi10.4238/2011.November.4.5-
dc.identifier.wosWOS:000300617600044-
dc.rights.accessRightsAcesso aberto-
dc.identifier.fileWOS000300617600044.pdf-
dc.relation.ispartofGenetics And Molecular Research-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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