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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/11801
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dc.contributor.authorKuasne, Hellen-
dc.contributor.authorRodrigues, Iara Sant'Ana-
dc.contributor.authorFuganti, Paulo Emilio-
dc.contributor.authorLosi-Guembarovski, Roberta-
dc.contributor.authorIto, Kazuhiro-
dc.contributor.authorKishima, Marina O.-
dc.contributor.authorde Freitas Rodrigues, Marco Aurelio-
dc.contributor.authorRogatto, Silvia Regina-
dc.contributor.authordos Santos, Rodrigo Mattos-
dc.contributor.authorde Syllos Colus, Ilce Mara-
dc.date.accessioned2014-05-20T13:34:26Z-
dc.date.accessioned2016-10-25T16:52:08Z-
dc.date.available2014-05-20T13:34:26Z-
dc.date.available2016-10-25T16:52:08Z-
dc.date.issued2010-11-01-
dc.identifierhttp://dx.doi.org/10.3109/07357907.2010.483509-
dc.identifier.citationCancer Investigation. Philadelphia: Taylor & Francis Inc, v. 28, n. 9, p. 917-924, 2010.-
dc.identifier.issn0735-7907-
dc.identifier.urihttp://hdl.handle.net/11449/11801-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/11801-
dc.description.abstractThe study of genes involved in androgen pathway can contribute to a better knowledge of prostate cancer. Our aim was to examine if polymorphisms in prostate-specific antigen (PSA) and androgen receptor (AR) genes were involved in prostate cancer risk and aggressiveness. Genotypes were determined by PCR-RFLP (PSA) or using a 377 ABI DNA Sequencer (AR). PSA(G/G) genotype (OR = 1.78, 95% CI = 1.06-2.99) and AR short CAG repeats (OR = 1.89, 95% CI = 1.21-2.96) increased risk for prostate cancer and were related with tumor aggressiveness. About 38.3% of tumors showed microsatellite instability. In conclusion, polymorphisms in these genes may be indicated as potential biomarkers for prostate cancer.en
dc.description.sponsorshipFundação Araucária de Apoio ao Desenvolvimento Científico e Tecnológico do Paraná (FAADCT/PR)-
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.format.extent917-924-
dc.language.isoeng-
dc.publisherTaylor & Francis Inc-
dc.sourceWeb of Science-
dc.subjectAR geneen
dc.subjectGleason scoreen
dc.subjectHistopathological parametersen
dc.subjectPolymorphismsen
dc.subjectProstate Canceren
dc.subjectPSA geneen
dc.titlePolymorphisms in the AR and PSA Genes as Markers of Susceptibility and Aggressiveness in Prostate Canceren
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)-
dc.contributor.institutionLondrina Hosp Canc-
dc.contributor.institutionHlth Sci Ctr-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniversidade Estadual de Londrina (UEL), Dept Gen Biol, Ctr Biol Sci, Londrina, Parana, Brazil-
dc.description.affiliationLondrina Hosp Canc, Londrina, Parana, Brazil-
dc.description.affiliationUniversidade Estadual de Londrina (UEL), Dept Pathol, Hlth Sci Ctr, Londrina, Parana, Brazil-
dc.description.affiliationHlth Sci Ctr, Dept Surg, Londrina, Parana, Brazil-
dc.description.affiliationSão Paulo State Univ Julio de Mesquita Filho, Fac Med Botucatu, São Paulo, Brazil-
dc.description.affiliationUnespSão Paulo State Univ Julio de Mesquita Filho, Fac Med Botucatu, São Paulo, Brazil-
dc.identifier.doi10.3109/07357907.2010.483509-
dc.identifier.wosWOS:000282753800005-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofCancer Investigation-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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