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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/12045
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dc.contributor.authorSilva-Filho, A. L.-
dc.contributor.authorTraiman, Paulo-
dc.contributor.authorTriginelli, S. A.-
dc.contributor.authorReis, F. M.-
dc.contributor.authorPedrosa, M. S.-
dc.contributor.authorMiranda, D.-
dc.contributor.authorAbreu, E. S.-
dc.contributor.authorMacarenco, R.-
dc.contributor.authorCunha-Melo, JR-
dc.date.accessioned2014-05-20T13:35:05Z-
dc.date.accessioned2016-10-25T16:52:34Z-
dc.date.available2014-05-20T13:35:05Z-
dc.date.available2016-10-25T16:52:34Z-
dc.date.issued2006-03-01-
dc.identifierhttp://dx.doi.org/10.1111/j.1525-1438.2006.00362.x-
dc.identifier.citationInternational Journal of Gynecological Cancer. Oxford: Blackwell Publishing, v. 16, n. 2, p. 757-762, 2006.-
dc.identifier.issn1048-891X-
dc.identifier.urihttp://hdl.handle.net/11449/12045-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/12045-
dc.description.abstractThis study was undertaken to evaluate the association between the expression of CD31 in the tumor and the histopathologic findings in patients with carcinoma of the cervix. This study included prospectively 30 women, aged 46.6 +/- 10.7 years, with stage IB squamous cell carcinoma of the cervix submitted to radical hysterectomy from November 2001 to September 2002. Samples from the tumor were taken and immunohistochemically evaluated by a monoclonal antibody for CD31. Clinicopathologic characteristics such as stage, tumor size, grade of differentiation, lymphatic vascular space invasion (LVSI), parametrial involvement, and status of pelvic lymph nodes were also recorded. The clinical stage (FIGO) was IB1 in 22 patients (73.3%) and IB2 in 8 patients (26.7%). The expression of CD31 was significantly associated with tumor size and the presence of LVSI, but not with grade of differentiation and vaginal or parametrial involvement (P= 0.03, P= 0.032, P= 0.352, P= 0.208, and P= 0.242, respectively). on univariate analysis, the presence of pelvic lymph node metastasis was influenced by LVSI (P= 0.003) and CD31 expression (P= 0.032). However, on multivariate analysis, the presence of LVSI (P= 0.007) was the only independent predictor of pelvic lymph node metastasis. The CD31 expression in tumor is significantly associated with LVSI and tumor size in patients with early-stage squamous cell carcinoma of the cervix.en
dc.format.extent757-762-
dc.language.isoeng-
dc.publisherBlackwell Publishing-
dc.sourceWeb of Science-
dc.subjectangiogenesispt
dc.subjectcarcinomapt
dc.subjectCD31pt
dc.subjectcervixpt
dc.titleAssociation between CD31 expression and histopathologic features in stage IB squamous cell carcinoma of the cervixen
dc.typeoutro-
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniv Fed Minas Gerais, Sch Med, Dept Obstet & Gynecol, BR-30130100 Belo Horizonte, MG, Brazil-
dc.description.affiliationUniv Fed Minas Gerais, Dept Pathol, Belo Horizonte, MG, Brazil-
dc.description.affiliationUniv Estadual Paulista, Dept Obstet & Gynecol, Botucatu, SP, Brazil-
dc.description.affiliationUniv Estadual Paulista, Dept Pathol, São Paulo, Brazil-
dc.description.affiliationUniv Fed Minas Gerais, Dept Surg, Belo Horizonte, MG, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Dept Obstet & Gynecol, Botucatu, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Dept Pathol, São Paulo, Brazil-
dc.identifier.doi10.1111/j.1525-1438.2006.00362.x-
dc.identifier.wosWOS:000236943200046-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofInternational Journal of Gynecological Cancer-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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