You are in the accessibility menu

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/12140
Full metadata record
DC FieldValueLanguage
dc.contributor.authorCampos, Kleber Eduardo de-
dc.contributor.authorVolpato, Gustavo Tadeu-
dc.contributor.authorCalderon, Iracema de Mattos Paranhos-
dc.contributor.authorRudge, Marilza Vieira Cunha-
dc.contributor.authorDamasceno, Débora Cristina-
dc.date.accessioned2014-05-20T13:35:18Z-
dc.date.available2014-05-20T13:35:18Z-
dc.date.issued2008-02-01-
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2008005000001-
dc.identifier.citationBrazilian Journal of Medical and Biological Research. São Paulo: Assoc Bras Divulg Cientifica, v. 41, n. 2, p. 122-125, 2008.-
dc.identifier.issn0100-879X-
dc.identifier.urihttp://hdl.handle.net/11449/12140-
dc.description.abstractThe aim of the present study was to assess the reproductive parameters of obese Wistar rats and to determine the frequency of their obese adult offspring. Neonatal rats were divided into two groups: F-1 generation, induced to obesity by monosodium glutamate (MSG; F(1)MSG, N = 30), and rats given saline (F1CON, N = 13). At 90 days of age all animals were mated, producing the F-2 offspring (F2CON, N = 28; F(2)MSG, N = 15). Reproductive parameters (fertility, pregnancy, and delivery indexes) were evaluated in F-1 rats. F-2 newborns were weighed, and the obesity parameter for F-1 and F-2 generations was determined from months 5 to 7 of life. At month 7, periovarian fat was weighed and no differences were found. Mean newborn weight also did not differ. The F-1 and F(2)MSG groups presented approximately 90% of obese rats since month 5 of life, whereas F-1 and F2CON groups presented only 33%. There was no difference in periovarian weight among groups. Although obesity did not affect reproductive parameters, obese dams (F(1)MSG) were responsible for the appearance of obesity in the subsequent generation. Thus, obesity induced by neonatal MSG administration did not interfere with reproduction, but did provide a viable model for obesity in second-generation adult Wistar rats. This model might contribute to a better understanding of the pathophysiological mechanisms involved in transgenerational obesity.en
dc.format.extent122-125-
dc.language.isoeng-
dc.publisherAssociação Brasileira de Divulgação Científica (ABRADIC)-
dc.sourceWeb of Science-
dc.subjectobesityen
dc.subjectoffspringen
dc.subjectfertilityen
dc.subjectWistar ratsen
dc.subjectmonosodium glutamateen
dc.subjecttransgenerationen
dc.titleEffect of obesity on rat reproduction and on the development of their adult offspringen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUNESP, Dept Obstet & Ginecol, Fac Med Botucatu, BR-18618000 Botucatu, SP, Brazil-
dc.description.affiliationUnespUNESP, Dept Obstet & Ginecol, Fac Med Botucatu, BR-18618000 Botucatu, SP, Brazil-
dc.identifier.doi10.1590/S0100-879X2008005000001-
dc.identifier.scieloS0100-879X2008000200008-
dc.identifier.wosWOS:000253337700008-
dc.rights.accessRightsAcesso aberto-
dc.identifier.fileWOS000253337700008.pdf-
dc.relation.ispartofBrazilian Journal of Medical and Biological Research-
dc.identifier.orcid0000-0002-9227-832X-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.
 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.