You are in the accessibility menu

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/12181
Full metadata record
DC FieldValueLanguage
dc.contributor.authorBraga, Antonio-
dc.contributor.authorGrowdon, Whitfield B.-
dc.contributor.authorBernstein, Marilyn-
dc.contributor.authorMaestá, Izildinha-
dc.contributor.authorRudge, Marilza Vieira Cunha-
dc.contributor.authorGoldstein, Donald P.-
dc.contributor.authorBerkowitz, Ross S.-
dc.date.accessioned2014-05-20T13:35:25Z-
dc.date.accessioned2016-10-25T16:52:49Z-
dc.date.available2014-05-20T13:35:25Z-
dc.date.available2016-10-25T16:52:49Z-
dc.date.issued2012-05-01-
dc.identifierhttp://www.reproductivemedicine.com/toc/auto_abstract.php?id=23967-
dc.identifier.citationJournal of Reproductive Medicine. St Louis: Sci Printers & Publ Inc, v. 57, n. 5-6, p. 225-230, 2012.-
dc.identifier.issn0024-7758-
dc.identifier.urihttp://hdl.handle.net/11449/12181-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/12181-
dc.description.abstractOBJECTIVE: To describe the clinical presentation of hydatidiform molar pregnancy in women under the age of 20 years. In addition, we sought to understand if this adolescent population manifests differences in clinical factors compared to an adult population that may affect outcome.STUDY DESIGN: We used a database from the New England Trophoblastic Disease Center to analyze clinical data from all women followed for molar pregnancy between 1970 and 2009 with complete follow-up information. This population was stratified by age and clinical parameters including presenting signs, molar histology and development of gestational trophoblastic neoplasia (GTN). Univariable and multivariable logistic regression was employed to discern clinical factors that associated with adolescent age. The Partners Human Research Committee approved this study.RESULTS: We identified 1,494 women diagnosed with hydatidiform mole (HM), of which 220 (14.7%) were adolescents defined as age <20 years. The most common presenting clinical signs were vaginal bleeding and an enlarged uterus compared to dates. Median gestational age at diagnosis was 13.4 weeks, not different from that in the adult population. Similarly, no difference in presenting human chorionic gonadotropin was observed between the adult and adolescent populations. Adolescents presented with a significant overrepresentation of complete mole (86% vs. 75%, p < 0.001) compared to adults. Complete mole was associated with a heightened risk of developing GTN (OR 2.6, 95% CI 1.9-3.5), and despite the association of complete mole with young maternal age, univariable analysis showed no difference in the rate of GTN observed between adolescents and adults (24% vs. 30%, p = 0.08). Multivariable analysis controlling for molar histology demonstrated that adolescent age was associated with a decreased risk of GTN (hazard ratio 0.67, 95% CI 0.48 0.93).CONCLUSION: Adolescents account for a substantial proportion of the population with HM. They commonly present with vaginal bleeding. Though this population develops a complete mole with a higher frequency than adults, adolescents appear to have a significantly decreased risk of developing GTN. (J Reprod Med 2012; 57:225-230)en
dc.format.extent225-230-
dc.language.isoeng-
dc.publisherSci Printers & Publ Inc-
dc.sourceWeb of Science-
dc.subjectadolescent pregnancyen
dc.subjectadolescentsen
dc.subjectgestational trophoblastic neoplasiaen
dc.subjecthydatidiform moleen
dc.subjectmolar pregnancyen
dc.titleMolar Pregnancy in Adolescentsen
dc.typeoutro-
dc.contributor.institutionBrigham & Womens Hosp-
dc.contributor.institutionUniversidade Federal Fluminense (UFF)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionMassachusetts Gen Hosp-
dc.contributor.institutionDonald P Goldstein MD Trophoblast Tumor Registry-
dc.contributor.institutionHarvard Univ-
dc.description.affiliationBrigham & Womens Hosp, Div Gynecol Oncol, Dept Obstet & Gynecol, Boston, MA 02115 USA-
dc.description.affiliationUniv Fed Fluminense, Trophoblast Dis Ctr, Univ Hosp Antonio Pedro, Niteroi, RJ, Brazil-
dc.description.affiliationUNESP São Paulo State Univ, Trophoblast Dis Ctr, Dept Gynecol & Obstet, Botucatu Med Sch, Botucatu, SP, Brazil-
dc.description.affiliationMassachusetts Gen Hosp, Div Gynecol Oncol, Dept Obstet & Gynecol, Harvard Canc Ctr,Dana Farber Canc Inst, Boston, MA 02114 USA-
dc.description.affiliationDonald P Goldstein MD Trophoblast Tumor Registry, New England Trophoblast Dis Ctr, Boston, MA USA-
dc.description.affiliationHarvard Univ, Sch Med, Boston, MA USA-
dc.description.affiliationUnespUNESP São Paulo State Univ, Trophoblast Dis Ctr, Dept Gynecol & Obstet, Botucatu Med Sch, Botucatu, SP, Brazil-
dc.identifier.wosWOS:000304738800009-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal of Reproductive Medicine-
dc.identifier.orcid0000-0002-9227-832X-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.
 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.