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dc.contributor.authorBannwart-Castro, Camila F.-
dc.contributor.authorPeraçoli, José Carlos-
dc.contributor.authorNakaira-Takahagi, E.-
dc.contributor.authorPeraçoli, Maria Terezinha Serrão-
dc.date.accessioned2014-05-20T13:35:25Z-
dc.date.accessioned2016-10-25T16:52:50Z-
dc.date.available2014-05-20T13:35:25Z-
dc.date.available2016-10-25T16:52:50Z-
dc.date.issued2010-01-01-
dc.identifierhttp://dx.doi.org/10.1080/14786410903314492-
dc.identifier.citationNatural Product Research. Abingdon: Taylor & Francis Ltd, v. 24, n. 18, p. 1747-1757, 2010.-
dc.identifier.issn1478-6419-
dc.identifier.urihttp://hdl.handle.net/11449/12185-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/12185-
dc.description.abstractSilibinin is a chemically defined flavonoid and the main active component of silymarin, a polyphenolic complex from Silybum marianum, which has anti-inflammatory, hepatoprotective and anticarcinogenic properties. Monocytes obtained from healthy individuals were incubated with silibinin to evaluate cell viability, hydrogen peroxide (H2O2) release and tumour necrosis factor-alpha (TNF-) production by these cells. The duration of treatment and different silibinin concentrations had no significant effect on cell viability. Monocytes showed a dose-dependent inhibitory effect on H2O2 release by phorbol myristate acetate-stimulated monocytes in silibinin concentrations ranging from 6.25 to 50 mu g mL-1. Significant inhibition of TNF- production by lipopolysaccharide-stimulated monocytes was observed at concentrations of 12.5, 50 and 100 mu g mL-1 of silibinin. These results suggest that silibinin exerts antioxidant and anti-inflammatory properties on human monocytes through an inhibitory effect on H2O2 release and on TNF- production, respectively.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.format.extent1747-1757-
dc.language.isoeng-
dc.publisherTaylor & Francis Ltd-
dc.sourceWeb of Science-
dc.subjecthydrogen peroxideen
dc.subjectTNF-en
dc.subjectflavonoiden
dc.subjectsilibininen
dc.subjectmonocytesen
dc.titleInhibitory effect of silibinin on tumour necrosis factor-alpha and hydrogen peroxide production by human monocytesen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationSão Paulo State Univ, Dept Microbiol & Immunol, Biosci Inst, UNESP, BR-18618000 Botucatu, SP, Brazil-
dc.description.affiliationSão Paulo State Univ, Dept Gynecol & Obstet, Botucatu Med Sch, UNESP, BR-18618000 Botucatu, SP, Brazil-
dc.description.affiliationUnespSão Paulo State Univ, Dept Microbiol & Immunol, Biosci Inst, UNESP, BR-18618000 Botucatu, SP, Brazil-
dc.description.affiliationUnespSão Paulo State Univ, Dept Gynecol & Obstet, Botucatu Med Sch, UNESP, BR-18618000 Botucatu, SP, Brazil-
dc.description.sponsorshipIdFAPESP: 03/10476-0-
dc.identifier.doi10.1080/14786410903314492-
dc.identifier.wosWOS:000283687900011-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofNatural Product Research-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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