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DC Field | Value | Language |
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dc.contributor.author | Bannwart-Castro, Camila F. | - |
dc.contributor.author | Peraçoli, José Carlos | - |
dc.contributor.author | Nakaira-Takahagi, E. | - |
dc.contributor.author | Peraçoli, Maria Terezinha Serrão | - |
dc.date.accessioned | 2014-05-20T13:35:25Z | - |
dc.date.accessioned | 2016-10-25T16:52:50Z | - |
dc.date.available | 2014-05-20T13:35:25Z | - |
dc.date.available | 2016-10-25T16:52:50Z | - |
dc.date.issued | 2010-01-01 | - |
dc.identifier | http://dx.doi.org/10.1080/14786410903314492 | - |
dc.identifier.citation | Natural Product Research. Abingdon: Taylor & Francis Ltd, v. 24, n. 18, p. 1747-1757, 2010. | - |
dc.identifier.issn | 1478-6419 | - |
dc.identifier.uri | http://hdl.handle.net/11449/12185 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/12185 | - |
dc.description.abstract | Silibinin is a chemically defined flavonoid and the main active component of silymarin, a polyphenolic complex from Silybum marianum, which has anti-inflammatory, hepatoprotective and anticarcinogenic properties. Monocytes obtained from healthy individuals were incubated with silibinin to evaluate cell viability, hydrogen peroxide (H2O2) release and tumour necrosis factor-alpha (TNF-) production by these cells. The duration of treatment and different silibinin concentrations had no significant effect on cell viability. Monocytes showed a dose-dependent inhibitory effect on H2O2 release by phorbol myristate acetate-stimulated monocytes in silibinin concentrations ranging from 6.25 to 50 mu g mL-1. Significant inhibition of TNF- production by lipopolysaccharide-stimulated monocytes was observed at concentrations of 12.5, 50 and 100 mu g mL-1 of silibinin. These results suggest that silibinin exerts antioxidant and anti-inflammatory properties on human monocytes through an inhibitory effect on H2O2 release and on TNF- production, respectively. | en |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.format.extent | 1747-1757 | - |
dc.language.iso | eng | - |
dc.publisher | Taylor & Francis Ltd | - |
dc.source | Web of Science | - |
dc.subject | hydrogen peroxide | en |
dc.subject | TNF- | en |
dc.subject | flavonoid | en |
dc.subject | silibinin | en |
dc.subject | monocytes | en |
dc.title | Inhibitory effect of silibinin on tumour necrosis factor-alpha and hydrogen peroxide production by human monocytes | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | São Paulo State Univ, Dept Microbiol & Immunol, Biosci Inst, UNESP, BR-18618000 Botucatu, SP, Brazil | - |
dc.description.affiliation | São Paulo State Univ, Dept Gynecol & Obstet, Botucatu Med Sch, UNESP, BR-18618000 Botucatu, SP, Brazil | - |
dc.description.affiliationUnesp | São Paulo State Univ, Dept Microbiol & Immunol, Biosci Inst, UNESP, BR-18618000 Botucatu, SP, Brazil | - |
dc.description.affiliationUnesp | São Paulo State Univ, Dept Gynecol & Obstet, Botucatu Med Sch, UNESP, BR-18618000 Botucatu, SP, Brazil | - |
dc.description.sponsorshipId | FAPESP: 03/10476-0 | - |
dc.identifier.doi | 10.1080/14786410903314492 | - |
dc.identifier.wos | WOS:000283687900011 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Natural Product Research | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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