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http://acervodigital.unesp.br/handle/11449/12205
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DC Field | Value | Language |
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dc.contributor.author | Braga, Antonio | - |
dc.contributor.author | Maestá, Izildinha | - |
dc.contributor.author | Michelin, Odair Carlito | - |
dc.contributor.author | Gomes Delmanto, Lucia Regina | - |
dc.contributor.author | Consonni, Marcos | - |
dc.contributor.author | Rudge, Marilza Vieira Cunha | - |
dc.contributor.author | Belfort, Paulo | - |
dc.date.accessioned | 2014-05-20T13:35:28Z | - |
dc.date.accessioned | 2016-10-25T16:52:52Z | - |
dc.date.available | 2014-05-20T13:35:28Z | - |
dc.date.available | 2016-10-25T16:52:52Z | - |
dc.date.issued | 2009-03-01 | - |
dc.identifier | http://dx.doi.org/10.1016/j.ygyno.2008.10.027 | - |
dc.identifier.citation | Gynecologic Oncology. San Diego: Academic Press Inc. Elsevier B.V., v. 112, n. 3, p. 568-571, 2009. | - |
dc.identifier.issn | 0090-8258 | - |
dc.identifier.uri | http://hdl.handle.net/11449/12205 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/12205 | - |
dc.description.abstract | Objective. To evaluate maternal and perinatal outcomes of first pregnancy after chemotherapy for gestational trophoblastic neoplasia (GTN) in Brazilian patients.Methods. This study included 252 subsequent pregnancies after chemotherapy for GTN treated between 1960-2005. Correlations of maternal and perinatal outcomes with chemotherapy regimen (single or multiagent) and the time interval between chemotherapy completion and first subsequent pregnancy were investigated.Results. There was a significant increase in adverse maternal outcomes in women who conceived <6 months than 6-12 months (76.2% and 19.6%; p<0.0001; OR=13.12; CI 95%=3.87-44.40) and >12 months (76.2% and 21.7%; P<0.0001; OR=11.56; CI 95%=3.98-33.55) after chemotherapy. Spontaneous abortion frequency was higher <6 months (71.4%) than 6-12 months (17.6%; p<0.0001: OR=11.66; CI 95%=3.55-38.22) and >12 months (9.4%; p<0.0001: OR=23.97: CI 95%=8.21-69.91) after chemotherapy. There was no difference in adverse perinatal outcomes (stillbirth, fetal malformation, and preterm birth) related to the interval after chemotherapy and Subsequent pregnancy. The overall occurrence of adverse maternal and perinatal outcomes did not significantly differ between patients on single or multiagent regimens.Conclusion. Adverse maternal outcomes and spontaneous abortion were more frequent among patients who conceived within 6 months of chemotherapy completion. In these cases, careful prenatal monitoring and hCG level measurement 6 weeks after the completion of any new pregnancy are recommended. (C) 2008 Elsevier B.V. All rights reserved. | en |
dc.format.extent | 568-571 | - |
dc.language.iso | eng | - |
dc.publisher | Academic Press Inc. Elsevier B.V. | - |
dc.source | Web of Science | - |
dc.subject | Gestational trophoblastic neoplasia | en |
dc.subject | Chemotherapy | en |
dc.subject | First subsequent pregnancy outcome | en |
dc.title | Maternal and perinatal outcomes of first pregnancy after chemotherapy for gestational trophoblastic neoplasia in Brazilian women | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Gestat Trophoblast Neoplasia Ctr Santa Casa Miser | - |
dc.description.affiliation | São Paulo State Univ, UNESP, Botucatu Med Sch, Dept Gynecol & Obstet,Trophoblast Dis Ctr, Botucatu, SP, Brazil | - |
dc.description.affiliation | Gestat Trophoblast Neoplasia Ctr Santa Casa Miser, Rio de Janeiro, Brazil | - |
dc.description.affiliation | São Paulo State Univ, UNESP, Botucatu Med Sch, Dept Internal Med,Oncol Treatment Ctr, Botucatu, SP, Brazil | - |
dc.description.affiliationUnesp | São Paulo State Univ, UNESP, Botucatu Med Sch, Dept Gynecol & Obstet,Trophoblast Dis Ctr, Botucatu, SP, Brazil | - |
dc.description.affiliationUnesp | São Paulo State Univ, UNESP, Botucatu Med Sch, Dept Internal Med,Oncol Treatment Ctr, Botucatu, SP, Brazil | - |
dc.identifier.doi | 10.1016/j.ygyno.2008.10.027 | - |
dc.identifier.wos | WOS:000264162800025 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Gynecologic Oncology | - |
dc.identifier.orcid | 0000-0002-9227-832X | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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