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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/12205
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dc.contributor.authorBraga, Antonio-
dc.contributor.authorMaestá, Izildinha-
dc.contributor.authorMichelin, Odair Carlito-
dc.contributor.authorGomes Delmanto, Lucia Regina-
dc.contributor.authorConsonni, Marcos-
dc.contributor.authorRudge, Marilza Vieira Cunha-
dc.contributor.authorBelfort, Paulo-
dc.date.accessioned2014-05-20T13:35:28Z-
dc.date.accessioned2016-10-25T16:52:52Z-
dc.date.available2014-05-20T13:35:28Z-
dc.date.available2016-10-25T16:52:52Z-
dc.date.issued2009-03-01-
dc.identifierhttp://dx.doi.org/10.1016/j.ygyno.2008.10.027-
dc.identifier.citationGynecologic Oncology. San Diego: Academic Press Inc. Elsevier B.V., v. 112, n. 3, p. 568-571, 2009.-
dc.identifier.issn0090-8258-
dc.identifier.urihttp://hdl.handle.net/11449/12205-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/12205-
dc.description.abstractObjective. To evaluate maternal and perinatal outcomes of first pregnancy after chemotherapy for gestational trophoblastic neoplasia (GTN) in Brazilian patients.Methods. This study included 252 subsequent pregnancies after chemotherapy for GTN treated between 1960-2005. Correlations of maternal and perinatal outcomes with chemotherapy regimen (single or multiagent) and the time interval between chemotherapy completion and first subsequent pregnancy were investigated.Results. There was a significant increase in adverse maternal outcomes in women who conceived <6 months than 6-12 months (76.2% and 19.6%; p<0.0001; OR=13.12; CI 95%=3.87-44.40) and >12 months (76.2% and 21.7%; P<0.0001; OR=11.56; CI 95%=3.98-33.55) after chemotherapy. Spontaneous abortion frequency was higher <6 months (71.4%) than 6-12 months (17.6%; p<0.0001: OR=11.66; CI 95%=3.55-38.22) and >12 months (9.4%; p<0.0001: OR=23.97: CI 95%=8.21-69.91) after chemotherapy. There was no difference in adverse perinatal outcomes (stillbirth, fetal malformation, and preterm birth) related to the interval after chemotherapy and Subsequent pregnancy. The overall occurrence of adverse maternal and perinatal outcomes did not significantly differ between patients on single or multiagent regimens.Conclusion. Adverse maternal outcomes and spontaneous abortion were more frequent among patients who conceived within 6 months of chemotherapy completion. In these cases, careful prenatal monitoring and hCG level measurement 6 weeks after the completion of any new pregnancy are recommended. (C) 2008 Elsevier B.V. All rights reserved.en
dc.format.extent568-571-
dc.language.isoeng-
dc.publisherAcademic Press Inc. Elsevier B.V.-
dc.sourceWeb of Science-
dc.subjectGestational trophoblastic neoplasiaen
dc.subjectChemotherapyen
dc.subjectFirst subsequent pregnancy outcomeen
dc.titleMaternal and perinatal outcomes of first pregnancy after chemotherapy for gestational trophoblastic neoplasia in Brazilian womenen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionGestat Trophoblast Neoplasia Ctr Santa Casa Miser-
dc.description.affiliationSão Paulo State Univ, UNESP, Botucatu Med Sch, Dept Gynecol & Obstet,Trophoblast Dis Ctr, Botucatu, SP, Brazil-
dc.description.affiliationGestat Trophoblast Neoplasia Ctr Santa Casa Miser, Rio de Janeiro, Brazil-
dc.description.affiliationSão Paulo State Univ, UNESP, Botucatu Med Sch, Dept Internal Med,Oncol Treatment Ctr, Botucatu, SP, Brazil-
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Botucatu Med Sch, Dept Gynecol & Obstet,Trophoblast Dis Ctr, Botucatu, SP, Brazil-
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Botucatu Med Sch, Dept Internal Med,Oncol Treatment Ctr, Botucatu, SP, Brazil-
dc.identifier.doi10.1016/j.ygyno.2008.10.027-
dc.identifier.wosWOS:000264162800025-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofGynecologic Oncology-
dc.identifier.orcid0000-0002-9227-832X-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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