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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/123427
Title: 
Factorial design and characterization studies for articaine hydrochloride loaded alginate/chitosan nanoparticles
Author(s): 
Institution: 
Universidade Estadual Paulista (UNESP)
ISSN: 
2164-9634
Abstract: 
Nowadays, articaine hydrochloride (ATC) is a local anesthetic widely used in dental procedures, but its side effects include paresthesia and nerve injury. Alginate/chitosan nanoparticles (AG/CSnano) can be used as carrier for drugs, overcoming the problems. The aim of this work was to evaluate the factors (Calcium/alginate [Ca2+:AG] and Chitosan/alginate [CS:AG] mass ratios) influence on the average size, polydispersity index, zeta potential and encapsulation efficiency of ATC. AG/CSnano containing ATC were prepared by ionic pregelation method. A three-level factorial design was carried out and the factors varied were Ca2+/AG mass ratio and CS/AG mass ratio. There were obtained nanoparticles with size range of 340–550 nm and polydispersity index between 0.2 and 0.5, zeta potential range –19 and –22 mV and encapsulation efficiency of ATC in AG/Csnano between 22 and 45%. According to the results, the average size, polydispersity index and encapsulation efficiency were significantly affected to the variation of Ca2+/AG and CS/AG mass ratio, but the zeta potential didn't change significantly with factor variations. The factorial design showed it was possible to identify formulations that presented better results for the parameters measured. The factor chosen for the suitable formulations was the encapsulation efficiency. Through this parameter, one formulation was chosen with highest encapsulation efficiency of ATC and presented good colloidal stability parameters aiming future clinical applications.
Issue Date: 
2013
Citation: 
Journal of Colloid Science and Biotecnology, v. 2, n. 2, p. 146-152, 2013.
Time Duration: 
146-152
Keywords: 
  • AG/CS nanoparticles
  • Articaine
  • Drug delivery
  • Factorial design
URI: 
Access Rights: 
Acesso restrito
Type: 
outro
Source:
http://repositorio.unesp.br/handle/11449/123427
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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