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Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/123427
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dc.contributor.authorMelo, Nathalie Ferreira Silva-
dc.contributor.authorCampos, Estefânia Vangelie Ramos-
dc.contributor.authorPaula, Eneida de-
dc.contributor.authorRosa, André Henrique-
dc.contributor.authorFraceto, Leonardo Fernandes-
dc.date.accessioned2015-05-15T13:30:10Z-
dc.date.accessioned2016-10-25T20:48:25Z-
dc.date.available2015-05-15T13:30:10Z-
dc.date.available2016-10-25T20:48:25Z-
dc.date.issued2013-
dc.identifier.citationJournal of Colloid Science and Biotecnology, v. 2, n. 2, p. 146-152, 2013.-
dc.identifier.issn2164-9634-
dc.identifier.urihttp://hdl.handle.net/11449/123427-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/123427-
dc.description.abstractNowadays, articaine hydrochloride (ATC) is a local anesthetic widely used in dental procedures, but its side effects include paresthesia and nerve injury. Alginate/chitosan nanoparticles (AG/CSnano) can be used as carrier for drugs, overcoming the problems. The aim of this work was to evaluate the factors (Calcium/alginate [Ca2+:AG] and Chitosan/alginate [CS:AG] mass ratios) influence on the average size, polydispersity index, zeta potential and encapsulation efficiency of ATC. AG/CSnano containing ATC were prepared by ionic pregelation method. A three-level factorial design was carried out and the factors varied were Ca2+/AG mass ratio and CS/AG mass ratio. There were obtained nanoparticles with size range of 340–550 nm and polydispersity index between 0.2 and 0.5, zeta potential range –19 and –22 mV and encapsulation efficiency of ATC in AG/Csnano between 22 and 45%. According to the results, the average size, polydispersity index and encapsulation efficiency were significantly affected to the variation of Ca2+/AG and CS/AG mass ratio, but the zeta potential didn't change significantly with factor variations. The factorial design showed it was possible to identify formulations that presented better results for the parameters measured. The factor chosen for the suitable formulations was the encapsulation efficiency. Through this parameter, one formulation was chosen with highest encapsulation efficiency of ATC and presented good colloidal stability parameters aiming future clinical applications.en
dc.format.extent146-152-
dc.language.isoeng-
dc.sourceCurrículo Lattes-
dc.subjectAG/CS nanoparticlesen
dc.subjectArticaineen
dc.subjectDrug deliveryen
dc.subjectFactorial designen
dc.titleFactorial design and characterization studies for articaine hydrochloride loaded alginate/chitosan nanoparticlesen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Engenharia Ambiental, Sorocaba, Av. Três de Março, 511, Alto da Boa Vista, CEP 18087180, SP, Brasil-
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Engenharia Ambiental, Sorocaba, Av. Três de Março, 511, Alto da Boa Vista, CEP 18087180, SP, Brasil-
dc.identifier.doihttp://dx.doi.org/10.1166/jcsb.2013.1048-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal of Colloid Science and Biotecnology-
dc.identifier.orcid0000-0002-2042-018Xpt
dc.identifier.lattes5228846314663888-
dc.identifier.lattes9175058122742496-
dc.identifier.lattes5343212477106568-
dc.identifier.lattes4741480538883395-
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