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DC Field | Value | Language |
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dc.contributor.author | Vieira Jénior, Gerardo Magela | - |
dc.contributor.author | Rocha, Cláudia Quintino da | - |
dc.contributor.author | Rodrigues, Tamires de Souza | - |
dc.contributor.author | Hiruma-Lima, Clélia Akiko | - |
dc.contributor.author | Vilegas, Wagner | - |
dc.date.accessioned | 2015-05-15T13:30:28Z | - |
dc.date.accessioned | 2016-10-25T20:48:46Z | - |
dc.date.available | 2015-05-15T13:30:28Z | - |
dc.date.available | 2016-10-25T20:48:46Z | - |
dc.date.issued | 2014 | - |
dc.identifier | http://www.sciencedirect.com/science/article/pii/S030881461401214X | - |
dc.identifier.citation | Food Chemistry, 2014. | - |
dc.identifier.issn | 0308-8146 | - |
dc.identifier.uri | http://hdl.handle.net/11449/123591 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/123591 | - |
dc.description.abstract | Solanum paniculatum L. (Solanaceae) is a plant species widespread throughout tropical America, especially in the Brazilian Savanna region. It is used in Brazil for culinary purposes and in folk medicine to treat liver and gastric dysfunctions, as well as hangovers. Fractionation of the ethanolic extracts (70%) from aerial parts (leaves and twigs) of S. paniculatum led to the isolation of the two new saponins (22R, 23S, 25R)-3β, 6α, 23-trihydroxy-5α-spirostane 6-O-β-d-xylopyranosyl-(1″″ → 3″′)-O-[β-d-quinovopyranosyl(1″′ → 2′)]-O-[α-l-rhamnopyranosyl(1″ → 3′)]-O-β-d-quinovopyranoside (1) and diosgenin 3-O-β-d-glucopyranosyl(1″ → 6′)-O-β-d-glucopyranoside (2) together with four know compounds: caffeic acid (3), diosgenin β-d-glucopyranoside (4), rutin (5), and quercetin 3-O-α-l-rhamnopyranosyl (1″′ → 6″)-O-β-d-galactopyranoside (6). The structures of these compounds were elucidated by extensive use of 1D and 2D NMR experiments along with HRESIMS analyses. Different doses (31.25–500 mg/kg) of ethanolic extract of leaves from S. paniculatum were evaluated against gastric ulcer induced by ethanol in rats. The lower dose of extract able to promote antiulcer effect was 125 mg/kg. The treatment with S. paniculatum by oral route was able to decrease gastric lesion area and also reduced levels of myeloperoxidase (MPO) in the gastric mucosa. Our results reveal for the first time, steroidal saponins from S. paniculatum and the antiulcer effect of this species at this lower dose. | en |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.language.iso | eng | - |
dc.source | Currículo Lattes | - |
dc.subject | Solanaceae | en |
dc.subject | Solanum paniculatum | en |
dc.subject | Steroidal saponins | en |
dc.subject | Antiulcer activity | en |
dc.title | New steroidal saponins and antiulcer activity from Solanum paniculatum L. | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Federal do Mato Grosso (UFMT) | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | Universidade Estadual Paulista Júlio de Mesquita Filho, Campus do Litoral Paulista - Unidade São Vicente, São Vicente, Praça Infante Dom Henrique sn, Parque Bitarú, CEP 11330900, SP, Brasil | - |
dc.description.affiliationUnesp | Universidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Química Orgânica, Instituto de Química de Araraquara | - |
dc.description.affiliationUnesp | Universidade Estadual Paulista Júlio de Mesquita Filho, Campus do Litoral Paulista - Unidade São Vicente | - |
dc.description.affiliationUnesp | Universidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Fisiologia, Instituto de Biociências de Botucatu | - |
dc.identifier.doi | http://dx.doi.org/10.1016/j.foodchem.2014.08.005 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Food Chemistry | - |
dc.identifier.orcid | 0000-0002-8645-3777 | pt |
dc.identifier.lattes | 7927877224326837 | - |
dc.identifier.lattes | 3814504901386844 | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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