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http://acervodigital.unesp.br/handle/11449/12370
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DC Field | Value | Language |
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dc.contributor.author | Ferrao, Ygor A. | - |
dc.contributor.author | Shavitt, Rosell G. | - |
dc.contributor.author | Bedin, Nadia R. | - |
dc.contributor.author | de Mathis, Maria Eugenia | - |
dc.contributor.author | Lopes, Antonio Carlos | - |
dc.contributor.author | Fontenelle, Leonardo F. | - |
dc.contributor.author | Torres, Albina Rodrigues | - |
dc.contributor.author | Miguel, Euripedes C. | - |
dc.date.accessioned | 2014-05-20T13:35:56Z | - |
dc.date.accessioned | 2016-10-25T16:53:11Z | - |
dc.date.available | 2014-05-20T13:35:56Z | - |
dc.date.available | 2016-10-25T16:53:11Z | - |
dc.date.issued | 2006-08-01 | - |
dc.identifier | http://dx.doi.org/10.1016/j.jad.2006.04.019 | - |
dc.identifier.citation | Journal of Affective Disorders. Amsterdam: Elsevier B.V., v. 94, n. 1-3, p. 199-209, 2006. | - |
dc.identifier.issn | 0165-0327 | - |
dc.identifier.uri | http://hdl.handle.net/11449/12370 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/12370 | - |
dc.description.abstract | Some patients with obsessive-compulsive disorder (OCD) exhibit an unsatisfactory reduction in symptom severity despite being treated with all the available therapeutic alternatives. The clinical variables associated with treatment-refractoriness in OCD are inconsistently described in the literature.Methods: To investigate factors associated with treatment-reftactoriness of patients with OCD, we conducted a case-control study, comparing 23 patients with treatment-refractory OCD to 26 patients with treatment-responding OCD.Results: the factors associated with refractoriness of OCD were higher severity of symptoms since the onset of OCD (P < 0.001), chronic course (p=0.003), lack of a partner (p=0.037), unemployment (p=0.025), low economic status (p=0.015), presence of obsessive-compulsive symptoms of sexual/religious content (p=0.043), and higher scores on family accommodation (P < 0.001). Only the three latter variables remained significantly associated with treatment-reftactoriness after regression analyses. Limitations: small sample size, the biases and drawbacks inherent to a case-control study, and the inclusion criteria used to define the study groups may have limited the generalisation of the results.Conclusion: A major strength of this study is the systematic and structured evaluation of a vast array of variables related to the clinical expression of OCD, including epigenetic factors and ratings derived from instruments evaluating family accommodation. The presence of sexual/religious symptoms, low economic status and high modification on family function due to OCD were independently associated with, treatment-refractoriness. Future longitudinal studies are warranted to verify if these variables represent predictive factors of treatment non-response. (c) 2006 Elsevier B.V. All rights reserved. | en |
dc.format.extent | 199-209 | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.source | Web of Science | - |
dc.subject | obsessive-compulsive disorder | pt |
dc.subject | treatment response | pt |
dc.subject | predictive factors | pt |
dc.title | Clinical features associated to refractory obsessive-compulsive disorder | en |
dc.type | outro | - |
dc.contributor.institution | Universidade de São Paulo (USP) | - |
dc.contributor.institution | PROTOC | - |
dc.contributor.institution | Presidente Vargas Hosp | - |
dc.contributor.institution | Universidade Federal do Rio de Janeiro (UFRJ) | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | Univ São Paulo, Sch Med, Dept Psychiat, São Paulo, Brazil | - |
dc.description.affiliation | PROTOC, Psychiat Inst Obsess Compuls Spectrum Program, São Paulo, Brazil | - |
dc.description.affiliation | Presidente Vargas Hosp, Psychiat Serv, Porto Alegre, RS, Brazil | - |
dc.description.affiliation | Univ Fed Rio de Janeiro, Inst Psychiat, Rio de Janeiro, Brazil | - |
dc.description.affiliation | Univ Estadual Paulista, Dept Neurol & Psychiat, Botucatu Fac Med, São Paulo, Brazil | - |
dc.description.affiliationUnesp | Univ Estadual Paulista, Dept Neurol & Psychiat, Botucatu Fac Med, São Paulo, Brazil | - |
dc.identifier.doi | 10.1016/j.jad.2006.04.019 | - |
dc.identifier.wos | WOS:000239880600019 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Journal of Affective Disorders | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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