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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/125538
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dc.contributor.authorBasso, Fernanda G.-
dc.contributor.authorPansani, Taisa N.-
dc.contributor.authorSoares, Diana G.-
dc.contributor.authorScheffel, Débora L.-
dc.contributor.authorBagnato, Vanderlei S.-
dc.contributor.authorCosta, Carlos Alberto de Souza-
dc.contributor.authorHebling, Josimeri-
dc.date.accessioned2015-08-06T16:12:22Z-
dc.date.accessioned2016-10-25T20:53:07Z-
dc.date.available2015-08-06T16:12:22Z-
dc.date.available2016-10-25T20:53:07Z-
dc.date.issued2015-
dc.identifierhttp://onlinelibrary.wiley.com/doi/10.1111/php.12445/abstract-
dc.identifier.citationPhotochemistry and Photobiology, v. 91, n. 4, p. 952-956, 2015.-
dc.identifier.issn0031-8655-
dc.identifier.urihttp://hdl.handle.net/11449/125538-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/125538-
dc.description.abstractThis study evaluated the effects of LLLT on the expressionof inflammatory cytokines related to the development of oralmucositis by gingival fibroblasts. Primary gingival fibroblastswere seeded on 24-well plates (105cells/well) for 24 h. Freshserum-free culture medium (DMEM) was then added, andcells were placed in contact with LPS (Escherichia coli,1 lgmL1), followed by LLLT irradiation (LaserTABLE—InGaAsP diode prototype—780 nm, 25 mW) delivering 0,0.5, 1.5 or 3 J cm². Cells without contact with LPS werealso irradiated with the same energy densities. Gene expres-sion of TNF- a, IL-1b, IL-6 and IL-8 was evaluated by Real-Time PCR, and protein synthesis of these cytokines wasdetermined by enzyme-linked immunosorbent (ELISA) assay.Data were statistically analyzed by the Kruskal– Wallis test,complemented by the Mann–Whitney test (P < 0.05). LPStreatment increased the gene expression and protein synthesisof TNF-a, IL-6 and IL-8, while the expression of IL-1b wasnot affected. For LPS-treated groups, LLLT promoted signif-icant decreases in the expression of TNF-a, IL-6, and IL-8 at1.5 J cm2and 3 J cm2. These results demonstrate thatLLLT promoted a beneficial biomodulatory effect on theexpression of inflammatory cytokines related to oral mucosi-tis by human gingival fibroblasts.en
dc.format.extent952-956-
dc.language.isoeng-
dc.sourceCurrículo Lattes-
dc.titleBiomodulation of inflammatory cytokines related to oral mucositis by low-level laser therapyen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCAR)-
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Clínica Infantil, Faculdade de Odontologia de Araraquara, Araraquara, Rua Humaitá, 1680, Centro, CEP 14801-903, SP, Brasil-
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Clínica Infantil, Faculdade de Odontologia de Araraquara, Araraquara, Rua Humaitá, 1680, Centro, CEP 14801-903, SP, Brasil-
dc.identifier.doihttp://dx.doi.org/10.1111/php.12445-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofPhotochemistry and Photobiology-
dc.identifier.lattes8207097271172991-
dc.identifier.lattes4517484241515548-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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