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http://acervodigital.unesp.br/handle/11449/125701
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DC Field | Value | Language |
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dc.contributor.author | Pigossi, Suzane C. | - |
dc.contributor.author | Oliveira, Guilherme J. P. L. | - |
dc.contributor.author | Finoti, Livia S. | - |
dc.contributor.author | Nepomuceno, Rafael | - |
dc.contributor.author | Spolidorio, Luis Carlos | - |
dc.contributor.author | Rossa Júnior, Carlos | - |
dc.contributor.author | Ribeiro, Sidney J. L. | - |
dc.contributor.author | Saska, Sybele | - |
dc.contributor.author | Scarel-Caminaga, Raquel M. | - |
dc.date.accessioned | 2015-08-06T16:12:52Z | - |
dc.date.accessioned | 2016-10-25T20:53:29Z | - |
dc.date.available | 2015-08-06T16:12:52Z | - |
dc.date.available | 2016-10-25T20:53:29Z | - |
dc.date.issued | 2015 | - |
dc.identifier | http://onlinelibrary.wiley.com/doi/10.1002/jbm.a.35472/abstract | - |
dc.identifier.citation | Journal of Biomedical Materials Research, 2015. | - |
dc.identifier.issn | 1549-3296 | - |
dc.identifier.uri | http://hdl.handle.net/11449/125701 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/125701 | - |
dc.description.abstract | This study aimed to evaluate the potential of bacterial cellulose-hydroxyapatite (BC-HA) composites associated with osteogenic growth peptide (OGP) or pentapeptide OGP(10–14) in bone regeneration in critical-size calvarial defects in mice. In this study, the BC-HA, BC-HA-OGP, and BC-HA-OGP(10–14) membranes were analyzed at 3, 7, 15, 30, 60, and 90 days. In each period, the specimens were evaluated by micro-computed tomography (µCT), descriptive histology, gene expression of bone biomarkers by qPCR and VEGFR-2 (vascular endothelial growth factor) quantification by ELISA. Three days post-operative, Runx2, Tnfrsf11b and Bglap bone biomarkers were upregulated mainly by BC-HA OGP and BC-HA OGP(10–14) membranes, suggesting an acceleration of the osteoblast differentiation/activity with the use of these biomaterials. At 60 and 90 days, a high percentage of bone formation was observed by µCT for BC-HA and BC-HA OGP(10–14) membranes. High expression of some bone biomarkers, such as Alpl, Spp1, and Tnfrsf11b, was also observed for the same membranes on days 60 and 90. In conclusion, the BC-HA membrane promoted a better bone formation in critical-size mice calvarial defects. Nevertheless, incorporation of the peptides at the concentration of 10−9 mol L−1 did not improve bone regeneration potential in the long-term. | en |
dc.language.iso | eng | - |
dc.source | Currículo Lattes | - |
dc.subject | Biomaterial | en |
dc.subject | Bacterial cellulose | en |
dc.subject | Bone regeneration | en |
dc.subject | Osteogenic peptide | en |
dc.subject | Gene expression | en |
dc.title | Bacterial cellulose-hydroxyapatite composites with osteogenic growth peptide (OGP) or pentapeptide OGP on bone regeneration in critical-size calvarial defect model | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | Universidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Diagnóstico e Cirurgia, Faculdade de Odontologia de Araraquara, Araraquara, Rua Humaitá, 1680, Centro, CEP 14801903, SP, Brasil | - |
dc.description.affiliationUnesp | Universidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Diagnóstico e Cirurgia, Faculdade de Odontologia de Araraquara, Araraquara, Rua Humaitá, 1680, Centro, CEP 14801903, SP, Brasil | - |
dc.description.affiliationUnesp | Department of Oral Diagnosis and Surgery, School of Dentistry, UNESP—Univ, Estadual Paulista, Araraquara, SP, Brazil | - |
dc.description.affiliationUnesp | Department of Morphology, School of Dentistry, UNESP—Univ, Estadual Paulista, Araraquara, SP, Brazil | - |
dc.description.affiliationUnesp | Department of Physiology and Pathology, School of Dentistry, UNESP—Univ, Estadual Paulista, Araraquara, SP, Brazil | - |
dc.description.affiliationUnesp | Department of General and Inorganic Chemistry, Institute of Chemistry, UNESP—Univ, Estadual Paulista, Araraquara, SP, Brazil | - |
dc.identifier.doi | http://dx.doi.org/10.1002/jbm.a.35472 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Journal of Biomedical Materials Research. Part A | - |
dc.identifier.lattes | 7634063102292261 | - |
dc.identifier.lattes | 2640929291808415 | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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