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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/125701
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dc.contributor.authorPigossi, Suzane C.-
dc.contributor.authorOliveira, Guilherme J. P. L.-
dc.contributor.authorFinoti, Livia S.-
dc.contributor.authorNepomuceno, Rafael-
dc.contributor.authorSpolidorio, Luis Carlos-
dc.contributor.authorRossa Júnior, Carlos-
dc.contributor.authorRibeiro, Sidney J. L.-
dc.contributor.authorSaska, Sybele-
dc.contributor.authorScarel-Caminaga, Raquel M.-
dc.date.accessioned2015-08-06T16:12:52Z-
dc.date.accessioned2016-10-25T20:53:29Z-
dc.date.available2015-08-06T16:12:52Z-
dc.date.available2016-10-25T20:53:29Z-
dc.date.issued2015-
dc.identifierhttp://onlinelibrary.wiley.com/doi/10.1002/jbm.a.35472/abstract-
dc.identifier.citationJournal of Biomedical Materials Research, 2015.-
dc.identifier.issn1549-3296-
dc.identifier.urihttp://hdl.handle.net/11449/125701-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/125701-
dc.description.abstractThis study aimed to evaluate the potential of bacterial cellulose-hydroxyapatite (BC-HA) composites associated with osteogenic growth peptide (OGP) or pentapeptide OGP(10–14) in bone regeneration in critical-size calvarial defects in mice. In this study, the BC-HA, BC-HA-OGP, and BC-HA-OGP(10–14) membranes were analyzed at 3, 7, 15, 30, 60, and 90 days. In each period, the specimens were evaluated by micro-computed tomography (µCT), descriptive histology, gene expression of bone biomarkers by qPCR and VEGFR-2 (vascular endothelial growth factor) quantification by ELISA. Three days post-operative, Runx2, Tnfrsf11b and Bglap bone biomarkers were upregulated mainly by BC-HA OGP and BC-HA OGP(10–14) membranes, suggesting an acceleration of the osteoblast differentiation/activity with the use of these biomaterials. At 60 and 90 days, a high percentage of bone formation was observed by µCT for BC-HA and BC-HA OGP(10–14) membranes. High expression of some bone biomarkers, such as Alpl, Spp1, and Tnfrsf11b, was also observed for the same membranes on days 60 and 90. In conclusion, the BC-HA membrane promoted a better bone formation in critical-size mice calvarial defects. Nevertheless, incorporation of the peptides at the concentration of 10−9 mol L−1 did not improve bone regeneration potential in the long-term.en
dc.language.isoeng-
dc.sourceCurrículo Lattes-
dc.subjectBiomaterialen
dc.subjectBacterial celluloseen
dc.subjectBone regenerationen
dc.subjectOsteogenic peptideen
dc.subjectGene expressionen
dc.titleBacterial cellulose-hydroxyapatite composites with osteogenic growth peptide (OGP) or pentapeptide OGP on bone regeneration in critical-size calvarial defect modelen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Diagnóstico e Cirurgia, Faculdade de Odontologia de Araraquara, Araraquara, Rua Humaitá, 1680, Centro, CEP 14801903, SP, Brasil-
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Diagnóstico e Cirurgia, Faculdade de Odontologia de Araraquara, Araraquara, Rua Humaitá, 1680, Centro, CEP 14801903, SP, Brasil-
dc.description.affiliationUnespDepartment of Oral Diagnosis and Surgery, School of Dentistry, UNESP—Univ, Estadual Paulista, Araraquara, SP, Brazil-
dc.description.affiliationUnespDepartment of Morphology, School of Dentistry, UNESP—Univ, Estadual Paulista, Araraquara, SP, Brazil-
dc.description.affiliationUnespDepartment of Physiology and Pathology, School of Dentistry, UNESP—Univ, Estadual Paulista, Araraquara, SP, Brazil-
dc.description.affiliationUnespDepartment of General and Inorganic Chemistry, Institute of Chemistry, UNESP—Univ, Estadual Paulista, Araraquara, SP, Brazil-
dc.identifier.doihttp://dx.doi.org/10.1002/jbm.a.35472-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal of Biomedical Materials Research. Part A-
dc.identifier.lattes7634063102292261-
dc.identifier.lattes2640929291808415-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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