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DC Field | Value | Language |
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dc.contributor.author | Moraes, Davi José de Almeida | - |
dc.contributor.author | Machado, Benedito Honório | - |
dc.contributor.author | Zoccal, Daniel Breseghello | - |
dc.date.accessioned | 2015-08-06T16:12:57Z | - |
dc.date.accessioned | 2016-10-25T20:53:33Z | - |
dc.date.available | 2015-08-06T16:12:57Z | - |
dc.date.available | 2016-10-25T20:53:33Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Journal of Neurophysiology, v. 108, n. 2, p. 610-623, 2012. | - |
dc.identifier.issn | 0022-3077 | - |
dc.identifier.uri | http://hdl.handle.net/11449/125729 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/125729 | - |
dc.description.abstract | The involvement of glutamatergic neurotransmission in the rostral ventrolateral medulla/Bötzinger/pre-Bötzinger complexes (RVLM/BötC/pre-BötC) on the respiratory modulation of sympathoexcitatory response to peripheral chemoreflex activation (chemoreflex) was evaluated in the working heart-brain stem preparation of juvenile rats. We identified different types of baro- and chemosensitive presympathetic and respiratory neurons intermingled within the RVLM/BötC/pre-BötC. Bilateral microinjections of kynurenic acid (KYN) into the rostral aspect of RVLM (RVLM/BötC) produced an additional increase in frequency of the phrenic nerve (PN: 0.38 ± 0.02 vs. 1 ± 0.08 Hz; P < 0.05; n = 18) and hypoglossal (HN) inspiratory response (41 ± 2 vs. 82 ± 2%; P < 0.05; n = 8), but decreased postinspiratory (35 ± 3 vs. 12 ± 2%; P < 0.05) and late-expiratory (24 ± 4 vs. 2 ±1%; P < 0.05; n = 5) abdominal (AbN) responses to chemoreflex. Likewise, expiratory vagal (cVN; 67 ± 6 vs. 40 ± 2%; P < 0.05; n = 5) and expiratory component of sympathoexcitatory (77 ± 8 vs. 26 ± 5%; P < 0.05; n = 18) responses to chemoreflex were reduced after KYN microinjections into RVLM/BötC. KYN microinjected into the caudal aspect of the RVLM (RVLM/pre-BötC; n = 16) abolished inspiratory responses [PN (n = 16) and HN (n = 6)], and no changes in magnitude of sympathoexcitatory (n = 16) and expiratory (AbN and cVN; n = 10) responses to chemoreflex, producing similar and phase-locked vagal, abdominal, and sympathetic responses. We conclude that in relation to chemoreflex activation 1) ionotropic glutamate receptors in RVLM/BötC and RVLM/pre-BötC are pivotal to expiratory and inspiratory responses, respectively; and 2) activation of ionotropic glutamate receptors in RVLM/BötC is essential to the coupling of active expiration and sympathoexcitatory response. | en |
dc.format.extent | 610-623 | - |
dc.language.iso | eng | - |
dc.source | Currículo Lattes | - |
dc.subject | sympathoexcitation | en |
dc.subject | sympathetic–respiratory coupling | en |
dc.subject | chemoreflex | en |
dc.subject | respiratory control | en |
dc.subject | L-glutamate | en |
dc.title | Sympatho-excitation during chemoreflex active expiration is mediated by L-glutamate in the RVLM/Bötzinger complex of rats | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | Universidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Fisiologia e Patologia, Faculdade de Odontologia de Araraquara, Araraquara, Rua Humaitá, 1680, Centro, CEP 14801903, SP, Brasil | - |
dc.description.affiliationUnesp | Universidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Fisiologia e Patologia, Faculdade de Odontologia de Araraquara, Araraquara, Rua Humaitá, 1680, Centro, CEP 14801903, SP, Brasil | - |
dc.identifier.doi | http://dx.doi.org/10.1152/jn.00057.2012 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Journal of Neurophysiology | - |
dc.identifier.lattes | 1958567557189244 | - |
dc.identifier.lattes | 1912911113942497 | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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