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dc.contributor.authorBassi, M.-
dc.contributor.authorFuruya, Werner I.-
dc.contributor.authorZoccal, D. B.-
dc.contributor.authorMenani, Jose Vanderlei-
dc.contributor.authorColombari, E.-
dc.contributor.authorHall, J. E.-
dc.contributor.authorSilva, A. A. da-
dc.contributor.authorCarmo, Jussara Márcia do-
dc.contributor.authorColombari, D. S. A.-
dc.identifier.citationLife Sciences, v. 2015, p. 25-31, 2015.-
dc.description.abstractLeptin, a peptide hormone produced by adipose tissue, acts in brain centers that control critical physiological functions such as metabolism, breathing and cardiovascular regulation. The importance of leptin for respiratory control is evident by the fact that leptin deficient mice exhibit impaired ventilatory responses to carbon dioxide (CO2), which can be corrected by intracerebroventricular leptin replacement therapy. Leptin is also recognized as an important link between obesity and hypertension. Humans and animal models lacking either leptin or functional leptin receptors exhibit many characteristics of the metabolic syndrome, including hyperinsulinemia, insulin resistance, hyperglycemia, dyslipidemia and visceral adiposity, but do not exhibit increased sympathetic nerve activity (SNA) and have normal to lower blood pressure (BP) compared to lean controls. Even though previous studies have extensively focused on the brain sites and intracellular signaling pathways involved in leptin effects on food intake and energy balance, the mechanisms that mediate the actions of leptin on breathing and cardiovascular function are only beginning to be elucidated. This mini-review summarizes recent advances on the effects of leptin on cardiovascular and respiratory control with emphasis on the neural control of respiratory function and autonomic activity.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.description.sponsorshipNational Institutes of Health (NIH)-
dc.sourceCurrículo Lattes-
dc.subjectSympathetic nerve activityen
dc.subjectBlood pressureen
dc.titleControl of respiratory and cardiovascular functions by leptinen
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversity of Mississippi Medical Center-
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Fisiologia e Patologia, Departamento de Fisiologia e Patologia, Araraquara, Rua Humaitá, 1680, Centro, CEP 14801903, SP, Brasil-
dc.description.affiliationDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA-
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Fisiologia e Patologia, Departamento de Fisiologia e Patologia, Araraquara, Rua Humaitá, 1680, Centro, CEP 14801903, SP, Brasil-
dc.description.sponsorshipIdFAPESP: 2009/54888–7-
dc.description.sponsorshipIdNHLBI: PO1 HL51971-
dc.description.sponsorshipIdNIGMS: P20GM104357-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofLife Sciences-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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