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dc.contributor.authorMoraes, Davi José de Almeida-
dc.contributor.authorSilva, Melina P. da-
dc.contributor.authorBonagamba, Leni Gomes Heck-
dc.contributor.authorMecawi, André de Souza-
dc.contributor.authorZoccal, Daniel Breseghello-
dc.contributor.authorAntunes-Rodrigues, José-
dc.contributor.authorVaranda, Wamberto Antonio-
dc.contributor.authorMachado, Benedito Honório-
dc.identifier.citationThe Journal of Neuroscience, v. 33, n. 49, p. 19223-19237, 2013.-
dc.description.abstractThe respiratory pattern generator modulates the sympathetic outflow, the strength of which is enhanced by challenges produced by hypoxia. This coupling is due to the respiratory-modulated presympathetic neurons in the rostral ventrolateral medulla (RVLM), but the underlining electrophysiological mechanisms remain unclear. For a better understanding of the neural substrates responsible for generation of this respiratory-sympathetic coupling, we combined immunofluorescence, single cell qRT-pCR, and electrophysiological recordings of the RVLM presympathetic neurons in in situ preparations from normal rats and rats submitted to a metabolic challenge produced by chronic intermittent hypoxia (CIH). Our results show that the spinally projected cathecholaminergic C1 and non-C1 respiratory-modulated RVLM presympathetic neurons constitute a heterogeneous neuronal population regarding the intrinsic electrophysiological properties, respiratory synaptic inputs, and expression of ionic currents, albeit all neurons presented persistent sodium current-dependent intrinsic pacemaker properties after synaptic blockade. A specific subpopulation of non-C1 respiratory-modulated RVLM presympathetic neurons presented enhanced excitatory synaptic inputs from the respiratory network after CIH. This phenomenon may contribute to the increased sympathetic activity observed in CIH rats. We conclude that the different respiratory-modulated RVLM presympathetic neurons contribute to the central generation of respiratory-sympathetic coupling as part of a complex neuronal network, which in response to the challenges produced by CIH contribute to respiratory-related increase in the sympathetic activity.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.sourceCurrículo Lattes-
dc.subjectBulbospinal RVLM presympathetic neuronsen
dc.subjectChronic intermittent hypoxiaen
dc.subjectIntrinsic electrophysiological propertiesen
dc.subjectRespiratory-sympathetic couplingen
dc.titleElectrophysiological properties of rostral ventrolateral medulla presympathetic neurons modulated by the respiratory network in ratsen
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniversidade de São Paulo, Departamento de Fisiologia, Faculdade de Medicina de Ribeirão Preto-
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Fisiologia e Patologia, Faculdade de Odontologia de Araraquara-
dc.description.sponsorshipIdFAPESP: 2009/50113-0-
dc.description.sponsorshipIdFAPESP: 2012/19750-7-
dc.description.sponsorshipIdFAPESP: 2011/24050-1-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofThe Journal of Neuroscience-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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