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Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/125792
Título: 
Relationship between levels of neuropeptide Substance P in periodontal disease and chronic pain: a literature review
Autor(es): 
Instituição: 
Universidade Estadual Paulista (UNESP)
ISSN: 
2041-1618
Resumo: 
The aim of the current review was to investigate the relationship between levels of neuropeptide Substance P in periodontal disease and chronic pain. Substance P is a neuropeptide that is directly related with pain. In periodontal disease, it is expressed during the inflammatory process, and is one of the factors responsible for bone resorption. Studies have shown that Substance P levels are highest in the gingival crevicular fluid from sites with active periodontal disease and bone loss. The persistence of these substances could be sufficient to stimulate neurogenic inflammation in susceptible tissues, and cause pain. The scientific literature shows that Substance P expressed during periodontal disease can be a risk factor for patients with systemic inflammatory pathologies, such as chronic arthritis or rheumatoid arthritis. Additional research is needed to confirm the participation of this substance in the origin of some types of chronic pain.
Data de publicação: 
2014
Citação: 
Journal of Investigative and Clinical Dentistry, v. 5, n. 2, p.91-97, 2014.
Duração: 
91-97
Palavras-chaves: 
  • chronic pain
  • neurogenic inflammation
  • periodontal disease
  • pro-inflammatory neuropeptide
  • Substance P
Endereço permanente: 
Direitos de acesso: 
Acesso restrito
Tipo: 
outro
Fonte completa:
http://repositorio.unesp.br/handle/11449/125792
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