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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/125797
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dc.contributor.authorRibeiro, Ana Paula Dias-
dc.contributor.authorAndrade, Mariana Carvalho-
dc.contributor.authorBagnato, Vanderlei Salvador-
dc.contributor.authorVergani, Carlos Eduardo-
dc.contributor.authorPrimo, Fernando Lucas-
dc.contributor.authorTedesco, Antônio Cláudio-
dc.contributor.authorPavarina, Ana Claudia-
dc.date.accessioned2015-08-06T16:13:08Z-
dc.date.accessioned2016-10-25T20:53:42Z-
dc.date.available2015-08-06T16:13:08Z-
dc.date.available2016-10-25T20:53:42Z-
dc.date.issued2013-
dc.identifierhttp://link.springer.com/article/10.1007%2Fs10103-013-1354-x-
dc.identifier.citationLasers in Medical Science, v. 30, n. 2, p. 549-559, 2013.-
dc.identifier.issn0268-8921-
dc.identifier.urihttp://hdl.handle.net/11449/125797-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/125797-
dc.description.abstractAntimicrobial photodynamic therapy represents an alternative method of killing resistant pathogens. Efforts have been made to develop delivery systems for hydrophobic drugs to improve the photokilling. This study evaluated the photodynamic effect of chloro-aluminum phthalocyanine (ClAlPc) encapsulated in nanoemulsions (NE) on methicillin-susceptible and methicillin-resistant Staphylococcus aureus suspensions and biofilms. Suspensions and biofilms were treated with different delivery systems containing ClAlPc. After the pre-incubation period, the drug was washed-out and irradiation was performed with LED source (660 ± 3 nm). Negative control samples were not exposed to ClAlPc or light. For the suspensions, colonies were counted (colony-forming units per milliliter (CFU/mL)). The metabolic activity of S. aureus suspensions and biofilms were evaluated by the XTT assay. The efficiency was dependent on the delivery system, superficial load and light dose. Cationic NE-ClAlPc and free-ClAlPc caused photokilling of the both strains of S. aureus. For biofilms, cationic NE-ClAlPc reduced cell metabolism by 80 and 73 % of susceptible and resistant strains, respectively. Although anionic NE-ClAlPc caused a significant CFU/ml reduction for MSSA and MRSA, it was not capable of reducing MRSA biofilm metabolism. This therapy may represent an alternative treatment for eradicating resistant strains.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.format.extent549-559-
dc.language.isoeng-
dc.sourceCurrículo Lattes-
dc.subjectAntimicrobial photodynamic therapyen
dc.subjectDrug delivery systemsen
dc.subjectPhthalocyanineen
dc.subjectMRSAen
dc.titleAntimicrobial photodynamic therapy against pathogenic bacterial suspensions and biofilms using chloro-aluminum phthalocyanine encapsulated in nanoemulsionsen
dc.typeoutro-
dc.contributor.institutionUniversidade de Brasília (UnB)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Materiais Odontológicos e Prótese, Faculdade de Odontologia de Araraquara, Araraquara, Rua Humaitá, 1680, Centro, CEP 14801903, SP, Brasil-
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Materiais Odontológicos e Prótese, Faculdade de Odontologia de Araraquara, Araraquara, Rua Humaitá, 1680, Centro, CEP 14801903, SP, Brasil-
dc.description.sponsorshipIdFAPESP: 2009/17975-9-
dc.description.sponsorshipIdFAPESP: 2010/05425-1-
dc.identifier.doihttp://dx.doi.org/10.1007/s10103-013-1354-x-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofLasers in Medical Science-
dc.identifier.lattes8867670539105403-
dc.identifier.lattes1531215699841687-
dc.identifier.lattes4947860249518663-
dc.identifier.lattes3003130522427820-
dc.identifier.lattes5809961609784365-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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