Please use this identifier to cite or link to this item:
http://acervodigital.unesp.br/handle/11449/12749
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bazo, A. P. | - |
dc.contributor.author | Rodrigues, MAM | - |
dc.contributor.author | Sforcin, José Mauricio | - |
dc.contributor.author | de Camargo, JLV | - |
dc.contributor.author | Ribeiro, Lúcia Regina | - |
dc.contributor.author | Salvadori, Daisy Maria Favero | - |
dc.date.accessioned | 2014-05-20T13:36:59Z | - |
dc.date.accessioned | 2016-10-25T16:53:50Z | - |
dc.date.available | 2014-05-20T13:36:59Z | - |
dc.date.available | 2016-10-25T16:53:50Z | - |
dc.date.issued | 2002-01-01 | - |
dc.identifier | http://dx.doi.org/10.1002/tcm.10011 | - |
dc.identifier.citation | Teratogenesis Carcinogenesis and Mutagenesis. New York: Wiley-liss, v. 22, n. 3, p. 183-194, 2002. | - |
dc.identifier.issn | 0270-3211 | - |
dc.identifier.uri | http://hdl.handle.net/11449/12749 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/12749 | - |
dc.description.abstract | Propolis is a honeybee product with several biological and therapeutical properties. Its effect on the process of colon carcinogenesis and DNA damage were evaluated in the male Wistar rats using the aberrant crypt foci (ACF) assay and the comet assay, respectively. For both tests, animals were treated with the colon carcinogen 1,2 dimethylhydrazine (DMH, 40 mg/kg, s.c.) for 2 weeks (two injections/week) in order to induce both DNA damage and ACF. The animals were divided into groups that received propolis (ethanolic extract) at three different doses (10, 30, and 90 mg/kg b.w., by gavage), either simultaneously or after DMH treatment. For the comet assay, peripheral blood samples were collected 4 h after the last DMH treatment. All animals were sacrificed at the 5th week for evaluation of ACF. The results show that only the intermediate dose (30 mg/kg) of propolis, administered after DMH initiation, is significantly associated to a smaller number of aberrant crypts in the distal colon. No effect on DNA damage in peripheral blood cells, however, was verified by the comet assay. These data suggest that propolis has a protective influence on the process of colon carcinogenesis, suppressing the development of preneoplastic lesions, and probably exerts no protection against the initiation of carcinogenesis. | en |
dc.format.extent | 183-194 | - |
dc.language.iso | eng | - |
dc.publisher | Wiley-Blackwell | - |
dc.source | Web of Science | - |
dc.subject | propolis | pt |
dc.subject | anticarcinogenesis | pt |
dc.subject | antimutagenesis | pt |
dc.subject | aberrant crypt foci assay | pt |
dc.subject | comet assay | pt |
dc.title | Protective action of propolis on the rat colon carcinogenesis | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | Univ Estadual Paulista Julio Mesquita Filho, Fac Med, Dept Patol, Botucatu, SP, Brazil | - |
dc.description.affiliation | Univ Estadual Paulista Julio Mesquita Filho, Inst Biociencias, Dept Microbiol & Imunol, Botucatu, SP, Brazil | - |
dc.description.affiliationUnesp | Univ Estadual Paulista Julio Mesquita Filho, Fac Med, Dept Patol, Botucatu, SP, Brazil | - |
dc.description.affiliationUnesp | Univ Estadual Paulista Julio Mesquita Filho, Inst Biociencias, Dept Microbiol & Imunol, Botucatu, SP, Brazil | - |
dc.identifier.doi | 10.1002/tcm.10011 | - |
dc.identifier.wos | WOS:000175234800003 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Teratogenesis Carcinogenesis and Mutagenesis | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.