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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/12798
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dc.contributor.authorPinheiro, P. F. F.-
dc.contributor.authorSegatelli, T. M.-
dc.contributor.authorFrancia, C. C. D. Almeida-
dc.contributor.authorMartinez, M.-
dc.contributor.authorPadovani, Carlos Roberto-
dc.contributor.authorFranchi, Marcos R.-
dc.contributor.authorMartinez, F. E.-
dc.date.accessioned2014-05-20T13:37:04Z-
dc.date.accessioned2016-10-25T16:53:54Z-
dc.date.available2014-05-20T13:37:04Z-
dc.date.available2016-10-25T16:53:54Z-
dc.date.issued2007-01-01-
dc.identifierhttp://dx.doi.org/10.1016/j.micron.2007.05.008-
dc.identifier.citationMicron. Oxford: Pergamon-Elsevier B.V., v. 38, n. 7, p. 734-746, 2007.-
dc.identifier.issn0968-4328-
dc.identifier.urihttp://hdl.handle.net/11449/12798-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/12798-
dc.description.abstractThe extreme use of ethanol causes metabolic and pathologic changes in testes and urogenital system in different animal species. The enzyme alcohol dehydrogenase (ADH) catalyses the conversion of ethanol into carcinogenic metabolite acetaldehyde which is partly excreted into the urine. However, papers relating the chronic ethanol consumption to the urethral morphology are unknown. This work evaluates the toxic effect of the chronic ethanol ingestion on the urethral epithelium of UChA and UChB rats. Conventional techniques of histology, histochemistry, immunohistochemistry and ultrastructural analysis were used. The analysis showed the presence of lipid drops and intercellular spaces in the epithelial cells in the urethra of UChA and UChB rats compared to control rats. Urethral neuroendocrine cell were observed and characterized for presenting vesicles containing electron-dense granules associated with nervous fibers. We conclude that the chronic consumption of ethanol induces the presence lipid drops in the epithelial cells of the urethra of UChA and UChB rats. The NE cells of the urethra of UChA and UChB rats did not show alterations under chronic effect of the ethanol. (C) 2007 Elsevier Ltd. All rights reserved.en
dc.format.extent734-746-
dc.language.isoeng-
dc.publisherElsevier B.V.-
dc.sourceWeb of Science-
dc.subjecturethrapt
dc.subjectUCh ratspt
dc.subjectexperimental alcoholismpt
dc.subjectneuroendocrine cellpt
dc.subjectmorphologypt
dc.titleMorphologic changes in the urethral epithelium in an ethanol-drinking rat strain (UChA and UChB)en
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)-
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)-
dc.description.affiliationUNESP, Dept Anat, Biosci Inst, BR-18618000 Botucatu, SP, Brazil-
dc.description.affiliationUniv Fed Minas Gerais, ICB, Dept Morphol, Belo Horizonte, MG, Brazil-
dc.description.affiliationUniv Fed Sao Carlos, Dept Morphol & Pathol, Sao Carlos, SP, Brazil-
dc.description.affiliationUNESP, IB, Dept Biostat, Botucatu, SP, Brazil-
dc.description.affiliationUNESP, FM, Dept Pathol, Botucatu, SP, Brazil-
dc.description.affiliationUnespUNESP, Dept Anat, Biosci Inst, BR-18618000 Botucatu, SP, Brazil-
dc.description.affiliationUnespUNESP, IB, Dept Biostat, Botucatu, SP, Brazil-
dc.description.affiliationUnespUNESP, FM, Dept Pathol, Botucatu, SP, Brazil-
dc.identifier.doi10.1016/j.micron.2007.05.008-
dc.identifier.wosWOS:000249320300006-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofMicron-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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