You are in the accessibility menu

Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorBonini, M. A.-
dc.contributor.authorJorge, R.-
dc.contributor.authorBarbosa, J. C.-
dc.contributor.authorCalucci, D.-
dc.contributor.authorCardillo, J. A.-
dc.contributor.authorCosta, R. A.-
dc.identifier.citationInvestigative Ophthalmology & Visual Science. Rockville: Associação Research Vision Ophthalmology Inc., v. 46, n. 10, p. 3845-3849, 2005.-
dc.description.abstractPURPOSE. To compare the effectiveness of posterior sub-Tenon's infusion (STi) and intravitreal injection (IVI) of triamcinolone acetonide (TA) for treatment of refractory diffuse diabetic macular edema.METHODS. Thirty-six phakic diabetic patients with refractory diffuse diabetic macular edema were prospectively enrolled. Patients randomly received either 40 mg STi or 4 mg IVI of TA. Comprehensive ophthalmic evaluation was performed at baseline and 1, 2, 4, 8 +/- 1, 12 +/- 2 and 24 +/- 2 weeks after treatment. Macular morphologic changes detected by optical coherence tomography and visual acuity, intraocular pressure, and lens status were evaluated.RESULTS. Twenty-eight patients (28 eyes) completed the 24-week study. Central macular thickness was significantly reduced in the IVI group when compared with the STi group at 2, 4, 8, 12, and 24 weeks after treatment (P < 0.01). Mean visual acuities (in logarithm of the minimum angle of resolution [logMAR]) at week-4, -8, and -12 follow-up examinations were significantly higher in the IVI group (0.74, 0.75, and 0.82, respectively) when compared with the STi group (0.88, 0.88, and 0.90, respectively; P < 0.01). A significant change from baseline in mean intraocular pressure (mm Hg) was seen at weeks 4 (+/- 3.21) and 8 (+/- 3.35) in STi the group (P < 0.01), and at week 8 (+/- 2.78) in the IVI group (P < 0.05). No patient had cataract progression during the study.CONCLUSIONS. Although the number of patients and length of follow-up in this preliminary study were limited, the changes in central macular thickness and visual acuity observed after treatment suggest that IVI TA may be more effective than STi for the management of refractory diffuse diabetic macular edema. Further studies are needed to confirm these preliminary findings.en
dc.publisherAssoc Research Vision Ophthalmology Inc-
dc.sourceWeb of Science-
dc.titleIntravitreal injection versus sub-Tenon's infusion of triamcinolone acetonide for refractory diabetic macular edema: A randomized clinical trialen
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionHosp Olhos Araraquara-
dc.description.affiliationUniv São Paulo, Dept Ophthalmol, Ribeirao Preto, SP, Brazil-
dc.description.affiliationUniv Estadual Paulista, Exact Sci Dept, Jaboticabal, SP, Brazil-
dc.description.affiliationHosp Olhos Araraquara, Retina Diagnost & Treatment Div, Araraquara, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Exact Sci Dept, Jaboticabal, SP, Brazil-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofInvestigative Ophthalmology & Visual Science-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.