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http://acervodigital.unesp.br/handle/11449/128285
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DC Field | Value | Language |
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dc.contributor.author | Carvalho, Ana Lygia R. de | - |
dc.contributor.author | Vital, Roberto B. | - |
dc.contributor.author | Kakuda, Claudio M. | - |
dc.contributor.author | Braz, Jose R. C. | - |
dc.contributor.author | Castiglia, Yara M. M. | - |
dc.contributor.author | Braz, Leandro G. | - |
dc.contributor.author | Modolo, Marilia P. | - |
dc.contributor.author | Ribeiro, Odilon R. G. | - |
dc.contributor.author | Domingues, Maria A. | - |
dc.contributor.author | Modolo, Norma S. P. | - |
dc.date.accessioned | 2015-10-21T13:08:42Z | - |
dc.date.accessioned | 2016-10-25T20:59:14Z | - |
dc.date.available | 2015-10-21T13:08:42Z | - |
dc.date.available | 2016-10-25T20:59:14Z | - |
dc.date.issued | 2015-04-01 | - |
dc.identifier | http://www.tandfonline.com/doi/full/10.3109/0886022X.2015.1006118#.VglqkvlViko | - |
dc.identifier.citation | Renal Failure. London: Informa Healthcare, v. 37, n. 3, p. 526-530, 2015. | - |
dc.identifier.issn | 0886-022X | - |
dc.identifier.uri | http://hdl.handle.net/11449/128285 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/128285 | - |
dc.description.abstract | Background: Ischemic acute kidney injury is a common occurrence in the perioperative period and in critical patients admitted to intensive care units. The reestablishment of blood supply may worsen injury through the ischemia-reperfusion (I/R) mechanism. We investigated the effect of dexmedetomidine on the kidneys of rats subjected to an experimental I/R model. Methods: 34 rats anesthetized with isoflurane was undergone right nephrectomy and randomly assigned to four groups: Control C (saline solution); Dexmedetomidine D (dexmedetomidine); Sham S (saline solution); Sham with Dexmedetomidine SD (dexmedetomidine). The serum levels of neutrophil gelatinase-associated lipocalin (NGAL) were measured at time-points T1 (following stabilization), T2 (ischemia), T3 (reperfusion), T4 (12 h after of I/R). The kidneys were subjected to histological examination. Results: The NGAL levels were significantly higher at T4 compared with T1. Upon histological examination, the left kidneys in groups C and D exhibited a similar extent of cell injury. Conclusion: The levels of NGAL did not indicate either protection against or worsening of kidney injury. Histological examination for acute tubular necrosis showed that dexmedetomidine did not protect the kidneys from I/R. | en |
dc.format.extent | 526-530 | - |
dc.language.iso | eng | - |
dc.publisher | Informa Healthcare | - |
dc.source | Web of Science | - |
dc.subject | Histology | en |
dc.subject | Ischemia | en |
dc.subject | NGAL | en |
dc.subject | Rat | en |
dc.subject | Reperfusion | en |
dc.title | Dexmedetomidine on renal ischemia-reperfusion injury in rats: assessment by means of NGAL and histology | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | Univ Estadual Paulista, Botucatu Med Sch, Dept Anesthesiol, UNESP, BR-18618970 Botucatu, SP, Brazil | - |
dc.description.affiliationUnesp | Univ Estadual Paulista, Botucatu Med Sch, Dept Anesthesiol, UNESP, BR-18618970 Botucatu, SP, Brazil | - |
dc.identifier.doi | http://dx.doi.org/10.3109/0886022X.2015.1006118 | - |
dc.identifier.wos | WOS:000353657500027 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Renal Failure | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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