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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/128285
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dc.contributor.authorCarvalho, Ana Lygia R. de-
dc.contributor.authorVital, Roberto B.-
dc.contributor.authorKakuda, Claudio M.-
dc.contributor.authorBraz, Jose R. C.-
dc.contributor.authorCastiglia, Yara M. M.-
dc.contributor.authorBraz, Leandro G.-
dc.contributor.authorModolo, Marilia P.-
dc.contributor.authorRibeiro, Odilon R. G.-
dc.contributor.authorDomingues, Maria A.-
dc.contributor.authorModolo, Norma S. P.-
dc.date.accessioned2015-10-21T13:08:42Z-
dc.date.accessioned2016-10-25T20:59:14Z-
dc.date.available2015-10-21T13:08:42Z-
dc.date.available2016-10-25T20:59:14Z-
dc.date.issued2015-04-01-
dc.identifierhttp://www.tandfonline.com/doi/full/10.3109/0886022X.2015.1006118#.VglqkvlViko-
dc.identifier.citationRenal Failure. London: Informa Healthcare, v. 37, n. 3, p. 526-530, 2015.-
dc.identifier.issn0886-022X-
dc.identifier.urihttp://hdl.handle.net/11449/128285-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/128285-
dc.description.abstractBackground: Ischemic acute kidney injury is a common occurrence in the perioperative period and in critical patients admitted to intensive care units. The reestablishment of blood supply may worsen injury through the ischemia-reperfusion (I/R) mechanism. We investigated the effect of dexmedetomidine on the kidneys of rats subjected to an experimental I/R model. Methods: 34 rats anesthetized with isoflurane was undergone right nephrectomy and randomly assigned to four groups: Control C (saline solution); Dexmedetomidine D (dexmedetomidine); Sham S (saline solution); Sham with Dexmedetomidine SD (dexmedetomidine). The serum levels of neutrophil gelatinase-associated lipocalin (NGAL) were measured at time-points T1 (following stabilization), T2 (ischemia), T3 (reperfusion), T4 (12 h after of I/R). The kidneys were subjected to histological examination. Results: The NGAL levels were significantly higher at T4 compared with T1. Upon histological examination, the left kidneys in groups C and D exhibited a similar extent of cell injury. Conclusion: The levels of NGAL did not indicate either protection against or worsening of kidney injury. Histological examination for acute tubular necrosis showed that dexmedetomidine did not protect the kidneys from I/R.en
dc.format.extent526-530-
dc.language.isoeng-
dc.publisherInforma Healthcare-
dc.sourceWeb of Science-
dc.subjectHistologyen
dc.subjectIschemiaen
dc.subjectNGALen
dc.subjectRaten
dc.subjectReperfusionen
dc.titleDexmedetomidine on renal ischemia-reperfusion injury in rats: assessment by means of NGAL and histologyen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniv Estadual Paulista, Botucatu Med Sch, Dept Anesthesiol, UNESP, BR-18618970 Botucatu, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Botucatu Med Sch, Dept Anesthesiol, UNESP, BR-18618970 Botucatu, SP, Brazil-
dc.identifier.doihttp://dx.doi.org/10.3109/0886022X.2015.1006118-
dc.identifier.wosWOS:000353657500027-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofRenal Failure-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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