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dc.contributor.authorAzevedo, Vera Lucia Fernandes de-
dc.contributor.authorSantos, Paulo Sergio Santana-
dc.contributor.authorOliveira Jr, Gildàsio Silveira de-
dc.contributor.authorMódolo, Gabriel Pinheiro-
dc.contributor.authorDomingues, Maria Aparecida Custódio-
dc.contributor.authorCastiglia, Yara Marcondes Machado-
dc.contributor.authorVianna, Pedro Thadeu Galvão-
dc.contributor.authorVane, Luiz Antonio-
dc.contributor.authorMódolo, Norma Sueli Pinheiro-
dc.date.accessioned2014-05-20T13:37:10Z-
dc.date.available2014-05-20T13:37:10Z-
dc.date.issued2013-01-01-
dc.identifierhttp://dx.doi.org/10.1590/S0102-86502013000100002-
dc.identifier.citationActa Cirúrgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 28, n. 1, p. 05-09, 2013.-
dc.identifier.issn0102-8650-
dc.identifier.urihttp://hdl.handle.net/11449/12842-
dc.description.abstractPURPOSE: To compare fluid replacement therapy with Hydroxyethyl starch 6% (HES) versus Ringer's lactate (RL) in a rodent model of non-septic renal ischemia. METHODS: Forty male Wistar rats were randomized to receive HES 2 ml.kg-1.hr-1or RL 5 ml. kg-1.hr-1 that underwent 30 minutes of renal ischemia followed by reperfusion. Twelve hours after kidney ischemia, the kidneys were evaluated for histological changes. Serum NGAL levels were obtained at different times of the experimental protocol. RESULTS: Rodents in the HES group had a median (IQR) grade of renal injury 3 (3 to 5) compared to 2 (2 to 4) in the RL group (p=0.03). NGAL levels were not associated with the severity of kidney injury. CONCLUSION: Hydroxyethyl starch administration caused more kidney injury than Ringer's lactate in a non-infectious model of renal hypoperfusion.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.format.extent05-09-
dc.language.isoeng-
dc.publisherSociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia-
dc.sourceSciELO-
dc.subjectAcute Kidney Injuryen
dc.subjectFluid Therapyen
dc.subjectColloidsen
dc.subjectHetastarchen
dc.subjectRatsen
dc.titleThe effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in ratsen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionNorthwestern University (NU)-
dc.contributor.institutionSanta Casa Faculty of Medicine of São Paulo-
dc.description.affiliationUNESP Botucatu Medical School Postgraduate Program in Anesthesiology-
dc.description.affiliationNorthwestern University Feinberg School of Medicine Department of Anesthesiology-
dc.description.affiliationSanta Casa Faculty of Medicine of São Paulo-
dc.description.affiliationUNESP Botucatu Medical School Department of Pathology-
dc.description.affiliationUNESP Botucatu Medical School Department of Anesthesiology-
dc.description.affiliationUnespUNESP Botucatu Medical School Postgraduate Program in Anesthesiology-
dc.description.affiliationUnespUNESP Botucatu Medical School Department of Pathology-
dc.description.affiliationUnespUNESP Botucatu Medical School Department of Anesthesiology-
dc.description.sponsorshipIdFAPESP: 10/08562-0-
dc.identifier.doi10.1590/S0102-86502013000100002-
dc.identifier.scieloS0102-86502013000100002-
dc.identifier.wosWOS:000313866600001-
dc.rights.accessRightsAcesso aberto-
dc.identifier.fileS0102-86502013000100002.pdf-
dc.relation.ispartofActa Cirúrgica Brasileira-
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