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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/128571
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dc.contributor.authorPontillo, Alessandra-
dc.contributor.authorReis, Edione C.-
dc.contributor.authorBricher, Pamela N.-
dc.contributor.authorVianna, Priscila-
dc.contributor.authorDiniz, Solange-
dc.contributor.authorFernandes, Karla S.-
dc.contributor.authorChies, José A.-
dc.contributor.authorSandrim, Valeria-
dc.date.accessioned2015-10-21T13:11:06Z-
dc.date.accessioned2016-10-25T20:59:56Z-
dc.date.available2015-10-21T13:11:06Z-
dc.date.available2016-10-25T20:59:56Z-
dc.date.issued2015-06-01-
dc.identifierhttp://onlinelibrary.wiley.com/doi/10.1111/aji.12353/abstract-
dc.identifier.citationAmerican Journal Of Reproductive Immunology. Hoboken: Wiley-blackwell, v. 73, n. 6, p. 577-581, 2015.-
dc.identifier.issn1046-7408-
dc.identifier.urihttp://hdl.handle.net/11449/128571-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/128571-
dc.description.abstractProblem: Augmented levels of IL-1 ss have been pointed out as an important pathogenic factor for preeclampsia development. Inflammasome is the cytoplasmic complex responsible for pro-IL1 ss cleavage and IL-1 ss secretion. Aim of the study was to evaluate the association between polymorphisms in inflammasome'genes and preeclampsia. Method of study: Selected polymorphisms in inflammasome genes (NLRP1, NLRP3, CARD8, and IL1B) were analyzed in 286 Brazilian women with and 309 without preeclampsia. Results and Conlclusions: The NLRP1 variant rs12150220 (L155H) was associated with the development of preeclampsia (OR=1.58), suggesting a role of this inflammasome receptor in the pathogenesis of this multifactorial disorder.en
dc.format.extent577-581-
dc.language.isoeng-
dc.publisherWiley-Blackwell-
dc.sourceWeb of Science-
dc.subjectIL-1 ssen
dc.subjectInflammasomeen
dc.subjectNLRP1en
dc.subjectPreeclampsiaen
dc.titleNLRP1 L155H polymorphism is a risk factor for preeclampsia developmenten
dc.typeoutro-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Federal do Rio Grande do Sul (UFRS)-
dc.contributor.institutionSanta Casa de Belo Horizonte-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniversidade de São Paulo, Departamento de Imunologia, Instituto de Ciências Biomédicas-
dc.description.affiliationUniversidade Federal do Rio Grande do Sul, Departamento de Genética-
dc.description.affiliationUnespUniversidade Estadual Paulista, Departamento de Farmacologia, Instituto de Biociências de Botucatu-
dc.identifier.doihttp://dx.doi.org/10.1111/aji.12353-
dc.identifier.wosWOS:000354390000010-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofAmerican Journal Of Reproductive Immunology-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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