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dc.contributor.authorMateron, Elsa M.-
dc.contributor.authorWong, Ademar-
dc.contributor.authorKlein, Stanlei I.-
dc.contributor.authorLiu, Juewen-
dc.contributor.authorSotomayor, Maria D. P. T.-
dc.identifier.citationElectrochimica Acta. Oxford: Pergamon-elsevier Science Ltd, v. 158, p. 271-276, 2015.-
dc.description.abstractA screen printed electrode functionalized with multi-walled carbon nanotubes and factory modified with carboxyl groups (MWCNT-COOH/SPCEs) was characterized by cyclic voltammetry and differential pulse voltammetry in a NaCl (0.1 mol L-1, pH 7) solution containing 800 mu mol L-1 sodium dodecyl sulfate (SDS). The MWCNT-COOH/SDS/SPCEs sensor was tested for the detection and quantification of cisplatin. For solutions of cisplatin, the electrochemical analysis showed a linear correlation coefficient of 0.9974 to cisplatin at concentrations between 1.45 x 10(-5) and 1.0 x 10(-4) mol L-1, a sensitivity of 4.4 x 10(4) (+/- 1.0 x 10(3)) mu A L mol(-1), and detection and quantification limits of 4.6 x 10(-6) and 1.4 x 10(-5) mol L-1, respectively. The reproducibility of the sensor response evaluated by the analysis of three replicates, indicated a RSD of 3.91%. The excellent response of the MWCNT-COOH/SDS/SPCEs cisplatin sensor allowed it to be tested in samples of human blood serum whose levels of added cisplatin were monitored by the HPLC. The average error % (sensor/HPLC) of 3.4 indicates that the combined methodology of MWCNT-COOH modified SPCE and the addition of a surfactant such as dodecyl sulfate is a convenient alternative for the use of HPLC for cisplatin determination in biological samples. The methodology cannot be applied to non-ionizable antitumor drugs carboplatin, oxaliplatin, doxorubicin or gemcitabine. (C) 2015 Elsevier Ltd. All rights reserved.en
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.publisherElsevier B.V.-
dc.sourceWeb of Science-
dc.subjectScreen printed electrodeen
dc.subjectMulti-walled carbon nanotubes (MWCNT-COOH)en
dc.subjectSodium dodecyl sulphate (SDS)en
dc.subjectDifferential pulse voltammetryen
dc.titleMulti-walled carbon nanotubes modified screen-printed electrodes for cisplatin detectionen
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversity of Waterloo-
dc.description.affiliationDepartment of Chemistry and Waterloo Institute for Nanotechnology, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada N2L 3G1-
dc.description.affiliationUnespDepartment of Analytical Chemistry, Institute of Chemistry, State University of São Paulo (UNESP), 14801-970, Araraquara – SP, Brazil-
dc.description.affiliationUnespDepartment of Inorganic Chemistry, Institute of Chemistry, State University of São Paulo (UNESP), 14801-970, Araraquara – SP, Brazil.-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofElectrochimica Acta-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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