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dc.contributor.authorSantos, Luciana de A.-
dc.contributor.authorCavalheiro, Alberto J.-
dc.contributor.authorTempone, Andre G.-
dc.contributor.authorCorrea, Daniela S.-
dc.contributor.authorAlexandre, Tatiana R.-
dc.contributor.authorQuintiliano, Natalia F.-
dc.contributor.authorRodrigues-Oliveira, Andre F.-
dc.contributor.authorOliveira-Silva, Diogo-
dc.contributor.authorMartins, Roberto Carlos C.-
dc.contributor.authorLago, Joao Henrique G.-
dc.identifier.citationMolecules, v. 20, n. 5, p. 8168-8180, 2015.-
dc.description.abstractChagas'disease is caused by a parasitic protozoan and affects the poorest population in the world, causing high mortality and morbidity. As a result of the toxicity and long duration of current treatments, the discovery of novel and more efficacious drugs is crucial. In this work, the hexane extract from seeds of Porcelia macrocarpa R.E. Fries (Annonaceae) displayed in vitro antitrypanosomal activity against trypomastigote forms of T. cruzi by the colorimetric MTT assay (IC50 of 65.44 g/mL). Using chromatographic fractionation over SiO2, this extract afforded a fraction composed by one active compound (IC50 of 10.70 mu g/mL), which was chemically characterized as 12,14-octadecadiynoic acid (macrocarpic acid). Additionally, two new inactive acetylene compounds (,'-dimacro-carpoyl--oleylglycerol and -macrocarpoyl-'-oleylglycerol) were also isolated from the hexane extract. The complete characterization of the isolated compounds was performed by analysis of NMR and MS data as well as preparation of derivatives.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.publisherMdpi Ag-
dc.sourceWeb of Science-
dc.subjectPorcelia macrocarpaen
dc.subjectAcetylene derivativesen
dc.subjectTrypanosoma cruzien
dc.titleAntitrypanosomal acetylene fatty acid derivatives from the seeds of porcelia macrocarpa (annonaceae)en
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionAdolfo Lutz Inst-
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)-
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)-
dc.description.affiliationUniv Estadual Paulista, Inst Quim, Nucleo Bioensaios Biossintese &Ecofisiol Prod Na, BR-14800060 Araraquara, SP, Brazil-
dc.description.affiliationAdolfo Lutz Inst, Ctr Parasitol &Micol, BR-01246902 Sao Paulo, SP, Brazil-
dc.description.affiliationUniv Fed Sao Paulo, Inst Ciencias Ambientais Quim &Farmaceut, BR-09972270 Diadema, SP, Brazil-
dc.description.affiliationUniv Fed Rio de Janeiro, Inst Pesquisa Prod Nat, BR-21941902 Rio De Janeiro, RJ, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Departamento de Química Orgânica, Inst Quim, Nucleo Bioensaios Biossintese &Ecofisiol Prod Na, BR-14800060 Araraquara, SP, Brazil-
dc.description.sponsorshipIdCNPq: 300546/2012-2-
dc.description.sponsorshipIdCNPq: 471458/2012-0-
dc.description.sponsorshipIdFAPESP: 1998/01735-2-
dc.description.sponsorshipIdFAPESP: 2011/51739-0-
dc.description.sponsorshipIdFAPESP: 2012/18756-1-
dc.rights.accessRightsAcesso aberto-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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