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dc.contributor.authorMarques, Danuzia A.-
dc.contributor.authorCarvalho, Debora de-
dc.contributor.authorSilva, Glauber S. F. da-
dc.contributor.authorSzawka, Raphael E.-
dc.contributor.authorAnselmo-Franci, Janete A.-
dc.contributor.authorBicego, Kenia C.-
dc.contributor.authorGargaglioni, Luciane H.-
dc.identifier.citationJournal Of Applied Physiology. Bethesda: Amer Physiological Soc, v. 119, n. 1, p. 61-68, 2015.-
dc.description.abstractThe aim of this study was to examine how estrous cycle, ovariectomy, and hormonal replacement affect the respiratory [ventilation ((V)over dotE), tidal volume, and respiratory frequency], metabolic ((V)over dotO(2)), and thermoregulatory (body temperature) responses to hypercapnia (7% CO2) in female Wistar rats. The parameters were measured in rats during different phases of the estrous cycle, and also in ovariectomized (OVX) rats supplemented with 17 beta-estradiol (OVX + E-2), with a combination of E-2 and progesterone (OVX + E2P), or with corn oil (OVX + O, vehicle). All experiments were conducted on day 8 after ovariectomy. The intact animals did not present alterations during normocapnia or under hypercapnia in (V)over dotE, tidal volume, respiratory frequency, (V)over dotO(2), and (V)over dotE/(V)over dotO(2) in the different phases of the estrous cycle. However, body temperature was higher in female rats on estrus. Hormonal replacement did not change the ventilatory, thermoregulatory, or metabolic parameters during hypercapnia, compared with the OVX animals. Nevertheless, OVX + E-2, OVX + E2P, and OVX + O presented lower hypercapnic ventilatory responses compared with intact females on the day of estrus. Also, rats in estrus showed higher (V)over dotE and (V)over dotE/(V)over dotO(2) during hypercapnia than OVX animals. The data suggest that other gonadal factors, besides E-2 and P, are possibly involved in these responses.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.description.sponsorshipINCT-Fisiologia Comparada-
dc.publisherAmer Physiological Soc-
dc.sourceWeb of Science-
dc.subjectcycling ratsen
dc.titleVentilatory, metabolic, and thermal responses to hypercapnia in female rats: effects of estrous cycle, ovariectomy, and hormonal replacementen
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionFed Inst Para-
dc.contributor.institutionUniv Fed Minas Gerais-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.description.affiliationSao Paulo State Univ, UNESP FCAV Jaboticabal, Dept Anim Morphol &Physiol, Sao Paulo, Brazil-
dc.description.affiliationFed Inst Para, Belem, Para, Brazil-
dc.description.affiliationUniv Fed Minas Gerais, Inst Biol Sci, Dept Physiol &Biophys, Belo Horizonte, MG, Brazil-
dc.description.affiliationUniv Sao Paulo, Dent Sch Ribeirao Preto, Dept Morphol Stomatol &Physiol, Sao Paulo, Brazil-
dc.description.affiliationUnespSao Paulo State Univ, UNESP FCAV Jaboticabal, Dept Anim Morphol &Physiol, Sao Paulo, Brazil-
dc.description.sponsorshipIdFAPESP: 2012/19966-0-
dc.description.sponsorshipIdCNPq: 442560/2014-1-
dc.description.sponsorshipIdFAPESP: 2013/17606-9-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal Of Applied Physiology-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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