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DC Field | Value | Language |
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dc.contributor.author | Oliveira, Marcela Brito | - |
dc.contributor.author | Calixto, Giovana | - |
dc.contributor.author | Graminha, Marcia | - |
dc.contributor.author | Cerecetto, Hugo | - |
dc.contributor.author | Gonzalez, Mercedes | - |
dc.contributor.author | Chorilli, Marlus | - |
dc.date.accessioned | 2015-10-21T21:00:08Z | - |
dc.date.accessioned | 2016-10-25T21:09:05Z | - |
dc.date.available | 2015-10-21T21:00:08Z | - |
dc.date.available | 2016-10-25T21:09:05Z | - |
dc.date.issued | 2015-01-01 | - |
dc.identifier | http://www.hindawi.com/journals/bmri/2015/396894/ | - |
dc.identifier.citation | Biomed Research International. New York: Hindawi Publishing Corporation, v. 2015, p. 1-12, 2015. | - |
dc.identifier.issn | 2314-6133 | - |
dc.identifier.uri | http://hdl.handle.net/11449/129394 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/129394 | - |
dc.description.abstract | Cutaneous leishmaniasis (CL) is a resistant form of leishmaniasis that is caused by a parasite belonging to the genus Leishmania. FLU-loaded microemulsions (MEs) were developed by phase diagram for topical administration of fluconazole (FLU) as prominent alternative to combat CL. Three MEs called F1, F2, and F3 (F1-60% 50 M phosphate buffer at pH 7.4 (PB) as aqueous phase, 10% cholesterol (CHO) as oil phase, and 30% soy phosphatidylcholine/oil polyoxyl-60 hydrogenated castor oil/sodium oleate (3/8/6) (S) as surfactant; F2-50% PB, 10% CHO, and 40% S; F3-40% PB, 10% CHO, and 50 % S) were characterized by droplet size analysis, zeta potential analysis, X-ray diffraction, continuous flow, texture profile analysis, and in vitro bioadhesion. MEs presented pseudoplastic flow and thixotropy was dependent on surfactant concentration. Droplet size was not affected by FLU. FLU-loaded MEs improved the FLU safety profile that was evaluated using red cell haemolysis and in vitro cytotoxicity assays with J-774 mouse macrophages. FLU-unloaded MEs did not exhibit leishmanicidal activity that was performed using MTT colourimetric assays; however, FLU-loaded MEs exhibited activity. Therefore, these MEs have potential to modulate FLU action, being a promising platform for drug delivery systems to treat CL. | en |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | - |
dc.description.sponsorship | Programa de Apoio ao Desenvolvimento Científico (PADC) | - |
dc.description.sponsorship | Comision Sectorial de Investigacion Cientifica (CSIC) | - |
dc.format.extent | 1-12 | - |
dc.language.iso | eng | - |
dc.publisher | Hindawi Publishing Corporation | - |
dc.source | Web of Science | - |
dc.title | Development, characterization, and in vitro biological performance of fluconazole-loaded microemulsions for the topical treatment of cutaneous leishmaniasis | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Universidad de la República | - |
dc.description.affiliation | Universidad de la República, Departamento de Química Orgánica, Facultad de Química-Facultad de Ciencias | - |
dc.description.affiliationUnesp | Universidade Estadual Paulista, Departamento de Fármacos e Medicamentos, Faculdade de Ciências Farmacêuticas de Araraquara | - |
dc.description.affiliationUnesp | Universidade Estadual Paulista, Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas de Araraquara | - |
dc.description.sponsorshipId | CSIC: 610 | - |
dc.identifier.doi | http://dx.doi.org/10.1155/2015/396894 | - |
dc.identifier.wos | WOS:000348787400001 | - |
dc.rights.accessRights | Acesso aberto | - |
dc.identifier.file | WOS000348787400001.pdf | - |
dc.relation.ispartof | Biomed Research International | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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