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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/12945
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dc.contributor.authorSilveira, Sara Martoreli-
dc.contributor.authorDomingues, Maria Aparecida Custódio-
dc.contributor.authorButugan, Ossamu-
dc.contributor.authorBrentani, Maria Mitzi-
dc.contributor.authorRogatto, Silvia Regina-
dc.date.accessioned2014-05-20T13:37:25Z-
dc.date.accessioned2016-10-25T16:54:05Z-
dc.date.available2014-05-20T13:37:25Z-
dc.date.available2016-10-25T16:54:05Z-
dc.date.issued2012-04-01-
dc.identifierhttp://dx.doi.org/10.1002/hed.21767-
dc.identifier.citationHead and Neck-Journal For The Sciences and Specialties of The Head and Neck. Malden: Wiley-blackwell, v. 34, n. 4, p. 485-492, 2012.-
dc.identifier.issn1043-3074-
dc.identifier.urihttp://hdl.handle.net/11449/12945-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/12945-
dc.description.abstractBackground To better characterize the pathophysiology of juvenile nasopharyngeal angiofibroma (JNA), endothelial and stromal cells were evaluated by genomic imbalances in association with transcript expression levels of genes mapped on these altered regions.Methods. High-resolution comparative genomic hybridization (HR-CGH) was used in laser-captured endothelial and stromal cells from 9 JNAs. Ten genes were evaluated by quantitative real-timereverse transcription polymerase chain reaction (qRT-PCR) in 15 cases.Results. Although gains were more frequently detected in endothelial cells, 57% of chromosomal alterations were common by both components. Gene expression analyses revealed a positive correlation between endothelial and stromal components for ASPM, CDH1, CTNNB1, FGF18, and SUPT16H. A significant difference was found for FGF18 and AURKB overexpression in stromal cells and AR down-expression in endothelial cells.Conclusions. A similar pattern of gene expression and chromosomal imbalances in both exponents would suggest a common mechanism of functional regulation. AURKB, FGF18, and SUPT16H were identified as potential molecular markers in JNA. (C) 2011 Wiley Periodicals, Inc. Head Neck 34: 485-492, 2012en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.format.extent485-492-
dc.language.isoeng-
dc.publisherWiley-Blackwell-
dc.sourceWeb of Science-
dc.subjectjuvenile nasopharyngeal angiofibromasen
dc.subjectquantitative real-time RT-PCRen
dc.subjectchromosomal imbalancesen
dc.subjecthigh-resolution comparative genomic hybridizationen
dc.subjecttumor microenvironmenten
dc.titleTumor microenvironmental genomic alterations in juvenile nasopharyngeal angiofibromaen
dc.typeoutro-
dc.contributor.institutionAC Camargo Hosp-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.description.affiliationAC Camargo Hosp, NeoGene Lab, Canc & Treatment Res Ctr, Antonio Prudente Fdn, São Paulo, Brazil-
dc.description.affiliationSão Paulo State Univ, Dept Pathol, FMB, UNESP, Botucatu, SP, Brazil-
dc.description.affiliationUniv São Paulo, Dept Otorhinolaryngol, FMUSP, São Paulo, Brazil-
dc.description.affiliationUniv São Paulo, Dept Radiol, FMUSP, LIM24, São Paulo, Brazil-
dc.description.affiliationSão Paulo State Univ, Dept Urol, FMB, UNESP, Botucatu, SP, Brazil-
dc.description.affiliationUnespSão Paulo State Univ, Dept Pathol, FMB, UNESP, Botucatu, SP, Brazil-
dc.description.affiliationUnespSão Paulo State Univ, Dept Urol, FMB, UNESP, Botucatu, SP, Brazil-
dc.identifier.doi10.1002/hed.21767-
dc.identifier.wosWOS:000300980800005-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofHead and Neck: Journal for the Sciences and Specialties of the Head and Neck-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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