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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/129612
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dc.contributor.authorPinto, Meri Emili F.-
dc.contributor.authorBatista, Joao M.-
dc.contributor.authorKoehbach, Johannes-
dc.contributor.authorGaur, Pratibha-
dc.contributor.authorSharma, Abhinay-
dc.contributor.authorNakabashi, Myna-
dc.contributor.authorCilli, Eduardo Maffud-
dc.contributor.authorGiesel, Guilherme M.-
dc.contributor.authorVerli, Hugo-
dc.contributor.authorGruber, Christian W.-
dc.contributor.authorBlanch, Ewan W.-
dc.contributor.authorTavares, Joseam F.-
dc.contributor.authorSilva, Marcelo S. da-
dc.contributor.authorGarcia, Celia R. S.-
dc.contributor.authorBolzani, Vanderlan S.-
dc.date.accessioned2015-10-22T06:15:57Z-
dc.date.accessioned2016-10-25T21:15:56Z-
dc.date.available2015-10-22T06:15:57Z-
dc.date.available2016-10-25T21:15:56Z-
dc.date.issued2015-03-01-
dc.identifierhttp://pubs.acs.org/doi/abs/10.1021/np5007668-
dc.identifier.citationJournal Of Natural Products. Washington: Amer Chemical Soc, v. 78, n. 3, p. 374-380, 2015.-
dc.identifier.issn0163-3864-
dc.identifier.urihttp://hdl.handle.net/11449/129612-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/129612-
dc.description.abstractA new orbitide named ribifolin was isolated and characterized from Jatropha ribifolia using mass spectrometry, NMR spectroscopy, quantitative amino acid analysis, molecular dynamics/simulated annealing, and Raman optical activity measurements and calculations. Ribifolin (1) and its linear form (1a) were synthesized by solid-phase peptide synthesis, followed by evaluation of its antiplasmodial and cytotoxicity activities. Compound 1 was moderately effective (IC50 = 42 mu M) against the Plasmodium falciparum strain 3D7.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.format.extent374-380-
dc.language.isoeng-
dc.publisherAmer Chemical Soc-
dc.sourceWeb of Science-
dc.titleRibifolin, an orbitide from jatropha ribifolia, and its potential antimalarial activityen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniv Manchester-
dc.contributor.institutionUniv Queensland-
dc.contributor.institutionMed Univ Vienna-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Federal do Rio Grande do Sul (UFRGS)-
dc.contributor.institutionUniversidade Federal da Paraíba (UFPB)-
dc.description.affiliationUniversidade Estadual Paulista (UNESP), Instituto de Química (IQ), BR-14800060 Araraquara, SP, Brasil-
dc.description.affiliationUniv Manchester, Manchester Inst Biotechnol, Manchester M1 7DN, Lancs, England-
dc.description.affiliationUniv Manchester, Fac Life Sci, Manchester M1 7DN, Lancs, England-
dc.description.affiliationUniv Queensland, Sch Biomed Sci, St Lucia, Qld 4072, Australia-
dc.description.affiliationMed Univ Vienna, Ctr Physiol &Pharmacol, A-1090 Vienna, Austria-
dc.description.affiliationUniversidade de São Paulo (USP), Instituto de Biociências (IB), Departamento de Fisiologia, BR-05508900 São Paulo, Brasil-
dc.description.affiliationUniversidade Federal do Rio Grande do Sul (UFRGS), Ctr Biotechnol, BR-91500970 Porto Alegre, RS, Brasil-
dc.description.affiliationUniversidade Federal da Paraíba (UFPB), Lab Pharmaceut Technol, BR-58051970 João Pessoa, PB, Brasil-
dc.description.affiliationUnespUniversidade Estadual Paulista (UNESP), Instituto de Química (IQ), BR-14800060 Araraquara, SP, Brasil-
dc.description.sponsorshipIdFAPESP: 2010/52327-5-
dc.description.sponsorshipIdFAPESP: 2013/07600-3-
dc.description.sponsorshipIdCAPES: BEX: 9875/11-5-
dc.description.sponsorshipIdFAPESP: 2011/22339-4-
dc.description.sponsorshipIdFAPESP: 2012/13739-1-
dc.identifier.doihttp://dx.doi.org/10.1021/np5007668-
dc.identifier.wosWOS:000352033900006-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal Of Natural Products-
dc.identifier.orcid0000-0002-4767-0904pt
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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