Please use this identifier to cite or link to this item:
http://acervodigital.unesp.br/handle/11449/130376
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Moreira, Priscila R. | - |
dc.contributor.author | Maioli, Marcos A. | - |
dc.contributor.author | Medeiros, Hyllana C. D. | - |
dc.contributor.author | Guelfi, Marieli | - |
dc.contributor.author | Pereira, Flavia T. V. | - |
dc.contributor.author | Mingatto, Fabio E. | - |
dc.date.accessioned | 2015-11-03T18:26:02Z | - |
dc.date.accessioned | 2016-10-25T21:21:00Z | - |
dc.date.available | 2015-11-03T18:26:02Z | - |
dc.date.available | 2016-10-25T21:21:00Z | - |
dc.date.issued | 2014-09-29 | - |
dc.identifier | http://www.biolres.com/content/47/1/49 | - |
dc.identifier.citation | Biological Research. Santiago: Soc Biolgia Chile, v. 47, 7 p., 2014. | - |
dc.identifier.issn | 0716-9760 | - |
dc.identifier.uri | http://hdl.handle.net/11449/130376 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/130376 | - |
dc.description.abstract | Background: The liver is an important organ for its ability to transform xenobiotics, making the liver tissue a prime target for toxic substances. The carotenoid bixin present in annatto is an antioxidant that can protect cells and tissues against the deleterious effects of free radicals. In this study, we evaluated the protective effect of bixin on liver damage induced by carbon tetrachloride (CCl4) in rats.Results: The animals were divided into four groups with six rats in each group. CCl4 (0.125 mL kg(-1) body wt.) was injected intraperitoneally, and bixin (5.0 mg kg(-1) body wt.) was given by gavage 7 days before the CCl4 injection. Bixin prevented the liver damage caused by CCl4, as noted by the significant decrease in serum aminotransferases release. Bixin protected the liver against the oxidizing effects of CCl4 by preventing a decrease in glutathione reductase activity and the levels of reduced glutathione and NADPH. The peroxidation of membrane lipids and histopathological damage of the liver was significantly prevented by bixin treatment.Conclusion: Therefore, we can conclude that the protective effect of bixin against hepatotoxicity induced by CCl4 is related to the antioxidant activity of the compound. | en |
dc.format.extent | 7 | - |
dc.language.iso | eng | - |
dc.publisher | Soc Biolgia Chile | - |
dc.source | Web of Science | - |
dc.subject | Bixin | en |
dc.subject | Carbon tetrachloride | en |
dc.subject | Hepatotoxicity | en |
dc.subject | Oxidative stress | en |
dc.subject | Protective activity | en |
dc.title | Protective effect of bixin on carbon tetrachloride-induced hepatotoxicity in rats | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | UNESP Univ Estadual Paulista, Lab Bioquim Metab &Toxicol LaBMeT, BR-17900000 Dracena, SP, Brazil | - |
dc.description.affiliation | UNESP Univ Estadual Paulista, L MPE, BR-17900000 Dracena, SP, Brazil | - |
dc.description.affiliationUnesp | UNESP Univ Estadual Paulista, Lab Bioquim Metab &Toxicol LaBMeT, BR-17900000 Dracena, SP, Brazil | - |
dc.description.affiliationUnesp | UNESP Univ Estadual Paulista, L MPE, BR-17900000 Dracena, SP, Brazil | - |
dc.identifier.doi | http://dx.doi.org/10.1186/0717-6287-47-49 | - |
dc.identifier.wos | WOS:000348527800002 | - |
dc.rights.accessRights | Acesso aberto | - |
dc.identifier.file | WOS000348527800002.pdf | - |
dc.relation.ispartof | Biological Research | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.