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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/130655
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dc.contributor.authorSaad, Wilson Abrão-
dc.contributor.authorCamargo, Luiz Antonio de Arruda-
dc.contributor.authorRenzi, Antonio-
dc.contributor.authorLuca Junior, Laurival Antonio de-
dc.contributor.authorAntunes-Rodrigues, José-
dc.contributor.authorSaad, Willian Abrão-
dc.date.accessioned2014-05-27T11:17:27Z-
dc.date.accessioned2016-10-25T21:21:42Z-
dc.date.available2014-05-27T11:17:27Z-
dc.date.available2016-10-25T21:21:42Z-
dc.date.issued1992-01-06-
dc.identifierhttp://dx.doi.org/10.1016/0304-3940(92)90519-D-
dc.identifier.citationNeuroscience Letters. Clare: Elsevier Sci Ireland Ltd, v. 134, n. 2, p. 212-214, 1992.-
dc.identifier.issn0304-3940-
dc.identifier.urihttp://hdl.handle.net/11449/130655-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/130655-
dc.description.abstractIn the present study we investigated the effects of central (i.c.v.) and subcutaneous (s.c.) injections of a 2 μg dose of lisinopryl, an inhibitor of angiotensin I(ANGI)-converting enzyme (CE), on water intake. I.c.v. but not s.c. injection of lisinopryl abolished drinking in response to s.c. isoprenaline (100 μg/kg) and significantly reduced drinking in response to 24 h water deprivation or s.c. polyethylene glycol (30% w/v, 10 ml/kg). Lisinopryl had no effect on water intake induced by cellular dehydration (s.c. injection of hypertonic saline (2 M NaCl)). These results are consistent with the hypothesis that lisinopryl acts as a CE blocking agent in the brain. The thirst challenge induced by hypotension using isoprenaline acts primarily by generating ANGII systemically and centrally. The other thirst challenges such as cellular dehydration are independent of the ANGII in the brain. This conclusion was made possible by utilizing a new CE blocking agent at a smaller dose than normally used for other ANG I-CE inhibitors. © 1992.en
dc.format.extent212-214-
dc.language.isoeng-
dc.publisherElsevier B.V.-
dc.sourceScopus-
dc.subjectAngiotensin-
dc.subjectLateral ventricle-
dc.subjectLisinopryl-
dc.subjectWater intake-
dc.subjectLisinopril-
dc.subjectAnimal experiment-
dc.subjectFluid intake-
dc.subjectIntracerebroventricular drug administration-
dc.subjectMale-
dc.subjectNonhuman-
dc.subjectPriority journal-
dc.subjectRat-
dc.subjectSubcutaneous drug administration-
dc.subjectAngiotensin-Converting Enzyme Inhibitors-
dc.subjectAnimal-
dc.subjectCerebral Ventricles-
dc.subjectDrinking Behavior-
dc.subjectEnalapril-
dc.subjectInjections, Intraventricular-
dc.subjectInjections, Subcutaneous-
dc.subjectIsoproterenol-
dc.subjectLisinopril-
dc.subjectMale-
dc.subjectRats-
dc.subjectReference Values-
dc.subjectSaline Solution, Hypertonic-
dc.subjectSupport, Non-U.S. Gov't-
dc.subjectTime Factors-
dc.titleAlterations in the water intake caused by central inhibition of angiotensin-converting enzyme in the raten
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationDepartment of Physiology School of Dentistry Paulista State University, Araraquara, SP-
dc.description.affiliationUnespDepartment of Physiology School of Dentistry Paulista State University, Araraquara, SP-
dc.identifier.doi10.1016/0304-3940(92)90519-D-
dc.identifier.wosWOS:A1992HB71300016-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofNeuroscience Letters-
dc.identifier.scopus2-s2.0-0026527715-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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