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DC Field | Value | Language |
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dc.contributor.author | Ruggiero, J. | - |
dc.contributor.author | Xodo, L. E. | - |
dc.contributor.author | Ciana, A. | - |
dc.contributor.author | Manzini, G. | - |
dc.contributor.author | Quadrifoglio, F. | - |
dc.date.accessioned | 2015-12-07T15:29:19Z | - |
dc.date.accessioned | 2016-10-25T21:22:00Z | - |
dc.date.available | 2015-12-07T15:29:19Z | - |
dc.date.available | 2016-10-25T21:22:00Z | - |
dc.date.issued | 1992-02-11 | - |
dc.identifier | http://www.ncbi.nlm.nih.gov/pubmed/1536881 | - |
dc.identifier.citation | Biochimica Et Biophysica Acta, v. 1129, n. 3, p. 294-302, 1992. | - |
dc.identifier.issn | 0006-3002 | - |
dc.identifier.uri | http://hdl.handle.net/11449/130784 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/130784 | - |
dc.description.abstract | The equilibrium interaction of doxorubicin and its N-acetyl derivative with a series of purine-pyrimidine alternating polydeoxynucleotides has been studied through spectrofluorometry to assess the relevance of the electrostatic contribution to DNA intercalation. The results have shown that: (a) the suppression of the positive charge on the aminosugar has: (I) a profound negative effect on the free energy of intercalation, as expected, and (II) a negligible influence on the base specificity, which supports the notion of an essentially electrostatic effect of N-acetylation on intercalation; (b) a reasonably good accord with the demands of a polyelectrolytic model, due to Friedman and Manning, is found. | en |
dc.format.extent | 294-302 | - |
dc.language.iso | eng | - |
dc.source | PubMed | - |
dc.title | Charge effect in the interaction of doxorubicin and derivatives with polydeoxynucleotides | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | Physics Department, Institute of Biosciences, UNESP, São José do Rio Preto, Brazil. | - |
dc.description.affiliationUnesp | Physics Department, Institute of Biosciences, UNESP, São José do Rio Preto, Brazil. | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Biochimica Et Biophysica Acta | - |
dc.identifier.pubmed | 1536881 | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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