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dc.contributor.authorPassalacqua, Thais Gaban-
dc.contributor.authorDutra, Luiz Antonio-
dc.contributor.authorAlmeida, Letícia de-
dc.contributor.authorVelásquez, Angela Maria Arenas-
dc.contributor.authorTorres, Fábio Aurélio Esteves-
dc.contributor.authorYamasaki, Paulo Renato-
dc.contributor.authorSantos, Mariana Bastos dos-
dc.contributor.authorRegasini, Luis Octavio-
dc.contributor.authorMichels, Paul A. M.-
dc.contributor.authorBolzani, Vanderlan da Silva-
dc.contributor.authorGraminha, Marcia A. S.-
dc.date.accessioned2015-12-07T15:37:00Z-
dc.date.accessioned2016-10-25T21:23:44Z-
dc.date.available2015-12-07T15:37:00Z-
dc.date.available2016-10-25T21:23:44Z-
dc.date.issued2015-08-15-
dc.identifierhttp://dx.doi.org/10.1016/j.bmcl.2015.05.072-
dc.identifier.citationBioorganic and Medicinal Chemistry Letters, v. 25, n. 16, p. 3342-3345, 2015.-
dc.identifier.issn1464-3405-
dc.identifier.urihttp://hdl.handle.net/11449/131525-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/131525-
dc.description.abstractChalcones form a class of compounds that belong to the flavonoid family and are widely distributed in plants. Their simple structure and the ease of preparation make chalcones attractive scaffolds for the synthesis of a large number of derivatives enabling the evaluation of the effects of different functional groups on biological activities. In this Letter, we report the successful synthesis of a series of novel prenylated chalcones via Claisen-Schmidt condensation and the evaluation of their effect on the viability of the Trypanosomatidae parasites Leishmania amazonensis, Leishmania infantum and Trypanosoma cruzi.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.description.sponsorshipPró-Reitoria de Pesquisa da UNESP (PROPe)-
dc.description.sponsorshipFundação para o Desenvolvimento da UNESP (FUNDUNESP)-
dc.format.extent3342-3345-
dc.language.isoeng-
dc.publisherElsevier B. V.-
dc.sourcePubMed-
dc.subjectDrug discoveryen
dc.subjectLeishmania amazonensisen
dc.subjectLeishmania infantumen
dc.subjectLeishmanicidal activityen
dc.subjectPrenylated chalconeen
dc.subjectTrypanocidal activityen
dc.subjectTrypanosoma cruzien
dc.titleSynthesis and evaluation of novel prenylated chalcone derivatives as anti-leishmanial and anti-trypanosomal compoundsen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversity of Edinburgh-
dc.description.affiliationInstituto de Química (IQ), Universidade Estadual Paulista (UNESP), 14800-060 Araraquara, SP, Brasil-
dc.description.affiliationPrograma de Pós-Graduação em Biotecnologia, Brasil-
dc.description.affiliationFaculdade de Ciências Farmacêuticas (FCFAR), Universidade Estadual Paulista (UNESP), 14801-902 Araraquara, SP, Brasil-
dc.description.affiliationPrograma de Pós-Graduação em Ciências Farmacêuticas (FCFAR), Brasil-
dc.description.affiliationInstituto de Biociências, Letras e Ciências Exatas (IBILCE), Universidade Estadual Paulista (UNESP), 15054-000 São José do Rio Preto, SP, Brasil-
dc.description.affiliationInstitute of Structural and Molecular Biology, University of Edinburgh, UK-
dc.description.affiliationUnespInstituto de Química (IQ), Universidade Estadual Paulista (UNESP), 14800-060 Araraquara, SP, Brasil-
dc.description.affiliationUnespPrograma de Pós-Graduação em Biotecnologia, Brasil-
dc.description.affiliationUnespFaculdade de Ciências Farmacêuticas (FCFAR), Universidade Estadual Paulista (UNESP), 14801-902 Araraquara, SP, Brasil-
dc.description.affiliationUnespPrograma de Pós-Graduação em Ciências Farmacêuticas (FCFAR), Brasil-
dc.description.affiliationUnespInstituto de Biociências, Letras e Ciências Exatas (IBILCE), Universidade Estadual Paulista (UNESP), 15054-000 São José do Rio Preto, SP, Brasil-
dc.description.sponsorshipIdFAPESP: 2010/52327-5-
dc.description.sponsorshipIdFAPESP: 2010/16732-2-
dc.description.sponsorshipIdCNPq: 407588/2013-2-
dc.identifier.doi10.1016/j.bmcl.2015.05.072-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofBioorganic and Medicinal Chemistry Letters-
dc.identifier.pubmed26055530-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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