You are in the accessibility menu

Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorDantas, Rodrigo Tavares-
dc.contributor.authorJorge, Antônio Rafael Coelho-
dc.contributor.authorJorge, Roberta Jeane Bezerra-
dc.contributor.authorMenezes, Ramon Róseo Paula Pessoa Bezerra de-
dc.contributor.authorLima, Danya Bandeira-
dc.contributor.authorTorres, Alba Fabíola Costa-
dc.contributor.authorToyama, Marcos Hikari-
dc.contributor.authorMonteiro, Helena Serra Azul-
dc.contributor.authorMartins, Alice Maria Costa-
dc.identifier.citationToxicon : Official Journal Of The International Society On Toxinology, v. 104, p. 52-56, 2015.-
dc.description.abstractRenal alterations caused by Bothrops venom and its compounds are studied to understand these effects and provide the best treatment. Previously, we studied the renal effect of the whole venom of Bothrops marajoensis and its phospholipase A2 (PLA2), but these effects could not to be attributed to PLA2. To continue the study, we report in this short communication the effects of l-amino acid oxidase from B. marajoensis venom (LAAOBm) on renal function parameter alterations observed in the same model of isolated perfused kidney, as well as the cytotoxic effect on renal cells. LAAOBm caused a decrease in PP, RVR, UF, GFR, %TNa(+) and %TCl(-), very similar to the effects of whole venom using the same model. We also demonstrated its cytotoxicity in MDCK cells with IC50 of 2.5 μg/mL and late apoptotic involvement demonstrated by flow cytometry assays. In conclusion, we suggested that LAAOBm is a nephrotoxic compound of B. marajoensis venom.en
dc.publisherElsevier B. V.-
dc.subjectBothrops marajoensis venomen
dc.titlel-amino acid oxidase from Bothrops marajoensis causes nephrotoxicity in isolated perfused kidney and cytotoxicity in MDCK renal cellsen
dc.contributor.institutionUniversidade Federal do Ceará (UFC)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniversidade Federal do Ceará, Departamento de Fisiologia e Farmacologia, Faculdade de Medicina-
dc.description.affiliationUniversidade Federal do Ceará, Departamento de Análises Clínica e Toxicológica-
dc.description.affiliationUnespUniversidade Estadual Paulista, Departamento de Ciências Biológicas, Instituto de Biociências de São Vicente-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofToxicon : Official Journal Of The International Society On Toxinology-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.