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dc.contributor.authorMarinho, Aline Diogo-
dc.contributor.authorMorais, Isabel Cristina Oliveira de-
dc.contributor.authorLima, Dânya Bandeira-
dc.contributor.authorJorge, Antônio Rafael Coelho-
dc.contributor.authorJorge, Roberta Jeane Bezerra-
dc.contributor.authorMenezes, Róseo Paula Pessoa Bezerra de-
dc.contributor.authorMello, Clarissa Perdigão-
dc.contributor.authorPereira, Gustavo José da Silva-
dc.contributor.authorSilveira, João Alison de Moraes-
dc.contributor.authorToyama, Marcos Hikari-
dc.contributor.authorOrzáez, Mar-
dc.contributor.authorMartins, Alice Maria Costa-
dc.contributor.authorMonteiro, Helena Serra Azul-
dc.identifier.citationToxicon : Official Journal Of The International Society On Toxinology, v. 108, p. 126-133, 2015.-
dc.description.abstractSnake envenomation (Bothrops genus) is common in tropical countries and acute kidney injury is one of the complications observed in Bothrops snakebite with relevant morbidity and mortality. Here, we showed that Bothropoides pauloensis venom (BpV) decreased cell viability (IC50 of 7.5 μg/mL). Flow cytometry with annexin V and propidium iodide showed that cell death occurred predominantly by apoptosis and late apoptosis, through caspases 3 and 7 activation, mitochondrial membrane potential collapse and ROS overproduction. BpV reduced perfusion pressure, renal vascular resistance, urinary flow, glomerular filtration rate, percentage of sodium, chloride or potassium tubular transportation. These findings demonstrated that BpV cytotoxicity on renal epithelial cells might be responsible for the nephrotoxicity observed in isolated kidney.en
dc.description.sponsorshipCoordenadação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado do Ceará (FUNCAP)-
dc.publisherElsevier B. V.-
dc.subjectBothropoides pauloensisen
dc.subjectCell deathen
dc.subjectRenal effectsen
dc.titleBothropoides pauloensis venom effects on isolated perfused kidney and cultured renal tubular epithelial cellsen
dc.contributor.institutionUniversidade Federal do Ceará (UFC)-
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionCentro de Investigación Príncipe Felipe-
dc.description.affiliationUniversidade Federal do Ceará, Departamento de Fisiologia e Farmacologia, Faculdade de Medicina-
dc.description.affiliationUniversidade Federal do Ceará, Departamento de Análises Clínica e Toxicológica-
dc.description.affiliationUniversidade Federal de São Paulo, Departamento de Farmacologia-
dc.description.affiliationCentro de Investigación Príncipe Felipe, Department of Medicinal Chemistry-
dc.description.affiliationUnespUniversidade Estadual Paulista, Departamento de Ciências Biológicas, Instituto de Biociências de São Vicente-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofToxicon : Official Journal Of The International Society On Toxinology-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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