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DC Field | Value | Language |
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dc.contributor.author | Camargo, Gregório Miguel Ferreira de | - |
dc.contributor.author | Aspilcueta-Borquis, Rusbel Raul | - |
dc.contributor.author | Fortes, M. R. S. | - |
dc.contributor.author | Porto-Neto, R. | - |
dc.contributor.author | Cardoso, Diercles Francisco | - |
dc.contributor.author | Santos, D. J. A. | - |
dc.contributor.author | Lehnert, S. A. | - |
dc.contributor.author | Reverter, A. | - |
dc.contributor.author | Moore, S. S. | - |
dc.contributor.author | Tonhati, Humberto | - |
dc.date.accessioned | 2015-12-07T15:39:56Z | - |
dc.date.accessioned | 2016-10-25T21:24:05Z | - |
dc.date.available | 2015-12-07T15:39:56Z | - |
dc.date.available | 2016-10-25T21:24:05Z | - |
dc.date.issued | 2015-10-28 | - |
dc.identifier | http://dx.doi.org/10.1186/s12864-015-1986-2 | - |
dc.identifier.citation | BMC Genomics, v. 16, n. 1, p. 872-885, 2015. | - |
dc.identifier.issn | 1471-2164 | - |
dc.identifier.uri | http://hdl.handle.net/11449/131670 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/131670 | - |
dc.description.abstract | Asian buffaloes (Bubalus bubalis) have an important socio-economic role. The majority of the population is situated in developing countries. Due to the scarce resources in these countries, very few species-specific biotechnology tools exist and a lot of cattle-derived technologies are applied to buffaloes. However, the application of cattle genomic tools to buffaloes is not straightforward and, as results suggested, despite genome sequences similarity the genetic polymorphisms are different. The first SNP chip genotyping platform designed specifically for buffaloes has recently become available. Herein, a genome-wide association study (GWAS) and gene network analysis carried out in buffaloes is presented. Target phenotypes were six milk production and four reproductive traits. GWAS identified SNP with significant associations and suggested candidate genes that were specific to each trait and also genes with pleiotropic effect, associated to multiple traits. Network predictions of interactions between these candidate genes may guide further molecular analyses in search of disruptive mutations, help select genes for functional experiments and evidence metabolism differences in comparison to cattle. The cattle SNP chip does not offer an optimal coverage of buffalo genome, thereafter the development of new buffalo-specific genetic technologies is warranted. An annotated reference genome would greatly facilitate genetic research, with potential impact to buffalo-based dairy production. | en |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.format.extent | 872-885 | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central LTD | - |
dc.source | PubMed | - |
dc.subject | Bubalus bubalis | en |
dc.subject | SNP | en |
dc.subject | Reproduction | en |
dc.subject | Milk | en |
dc.subject | Candidate genes | en |
dc.subject | GWAS | en |
dc.title | Prospecting major genes in dairy buffaloes | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | University of Queensland | - |
dc.contributor.institution | Commonwealth Scientific and Industrial Research Organization | - |
dc.description.affiliation | Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias (FCAV), Universidade Estadual Paulista (UNESP), 14884-900 Jaboticabal, SP, Brasil | - |
dc.description.affiliation | School of Chemistry and Molecular Bioscience, University of Queensland, St Lucia, Brisbane, QLD, 4072, Australia | - |
dc.description.affiliation | Commonwealth Scientific and Industrial Research Organization, Agriculture Flagship, St Lucia, Brisbane, QLD, 4072, Australia | - |
dc.description.affiliation | Queensland Alliance for Agriculture and Food Innovation, Centre for Animal Science, University of Queensland, Brisbane, QLD, 4067, Australia | - |
dc.description.affiliationUnesp | Universidade Estadual Paulista, Departamento de Zootecnia, Faculdade de Ciências Agrárias e Veterinárias de Jaboticabal | - |
dc.description.sponsorshipId | FAPESP: 2010/20887-1 | - |
dc.description.sponsorshipId | FAPESP: 2013/12851-5 | - |
dc.identifier.doi | 10.1186/s12864-015-1986-2 | - |
dc.rights.accessRights | Acesso aberto | - |
dc.identifier.file | PMC4625573.pdf | - |
dc.relation.ispartof | BMC Genomics | - |
dc.identifier.pubmed | 26510479 | - |
dc.identifier.pmc | PMC4625573 | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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