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dc.contributor.authorNovaes, Letícia Celia de Lencastre-
dc.contributor.authorJozala, Angela Faustino-
dc.contributor.authorLopes, André Moreni-
dc.contributor.authorSantos-Ebinuma, Valéria de Carvalho-
dc.contributor.authorMazzola, Priscila Gava-
dc.contributor.authorPessoa Junior, Adalberto-
dc.identifier.citationBiotechnology Progress, 2015.-
dc.description.abstractBromelain is a cysteine protease found in pineapple tissue. Due to its anti-inflammatory and anti-cancer activities, as well as its ability to induce apoptotic cell death, bromelain has proved useful in several therapeutic areas. The market for this protease is growing, and several studies exploring various properties of this molecule have been reported. This review aims to compile this data, and summarize the main findings on bromelain in the literature to date. The physicochemical properties and stability of bromelain under different conditions are discussed. Several studies on the purification of bromelain from crude extracts using a wide range of techniques such as liquid-liquid extractions by aqueous two-phase system, ultrafiltration, precipitation, and chromatography, have been reported. Finally, the various applications of bromelain are presented. This review therefore covers the main properties of bromelain, aiming to provide an up-to-date compilation of the data reported on this enzyme.en
dc.publisherAmerican Institute of Chemical Engineers-
dc.subjectDownstream processesen
dc.titleStability, purification, and applications of bromelain: a reviewen
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.contributor.institutionUniversidade de Sorocaba (UNISO)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationDepartamento de Tecnologia Bioquímico-Farmacêutico, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo (USP), São Paulo, SP, Brasil-
dc.description.affiliationDepartamento de Patologia Clínica, Faculdade de Ciências Médicas, Universidade de Campinas (UNICAMP), Campinas, SP, Brasil-
dc.description.affiliationDepartamento de Farmácia, Faculdade de Ciências Farmacêuticas, Universidade de Sorocaba (UNISO), Sorocaba, SP, Brasil-
dc.description.affiliationDepartamento de Bioprocessos e Biotecnologia, Faculdade de Ciências Farmacêuticas (FCFAR), Universidade Estadual Paulista (UNESP), Araraquara, SP, Brasil-
dc.description.affiliationFaculdade de Ciências Farmacêuticas, Universidade de Campinas (UNICAMP), Campinas, SP, Brasil-
dc.description.affiliationUnespDepartamento de Bioprocessos e Biotecnologia, Faculdade de Ciências Farmacêuticas (FCFAR), Universidade Estadual Paulista (UNESP), Araraquara, SP, Brasil-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofBiotechnology Progress-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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