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dc.contributor.authorFreiria-Oliveira, André H.-
dc.contributor.authorBlanch, Graziela T.-
dc.contributor.authorPedrino, Gustavo R.-
dc.contributor.authorCravo, Sergio L.-
dc.contributor.authorMurphy, David-
dc.contributor.authorMenani, José V.-
dc.contributor.authorColombari, Débora S. A.-
dc.identifier.citationAmerican Journal Of Physiology. Regulatory, Integrative And Comparative Physiology, v. 309, n. 9, p. 1082-1091, 2015.-
dc.description.abstractNoradrenergic A2 neurons of the nucleus of the solitary tract (NTS) have been suggested to contribute to body fluid homeostasis and cardiovascular regulation. In the present study, we investigated the effects of lesions of A2 neurons of the commissural NTS (cNTS) on the c-Fos expression in neurons of the hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei, arterial pressure, water intake, and urinary excretion in rats with plasma hyperosmolality produced by intragastric 2 M NaCl (2 ml/rat). Male Holtzman rats (280-320 g) received an injection of anti-dopamine-β-hydroxylase-saporin (12.6 ng/60 nl; cNTS/A2-lesion, n = 28) or immunoglobulin G (IgG)-saporin (12.6 ng/60 nl; sham, n = 24) into the cNTS. The cNTS/A2 lesions increased the number of neurons expressing c-Fos in the magnocellular PVN in rats treated with hypertonic NaCl (90 ± 13, vs. sham: 47 ± 20; n = 4), without changing the number of neurons expressing c-Fos in the parvocellular PVN or in the SON. Contrary to sham rats, intragastric 2 M NaCl also increased arterial pressure in cNTS/A2-lesioned rats (16 ± 3, vs. sham: 2 ± 2 mmHg 60 min after the intragastric load; n = 9), an effect blocked by the pretreatment with the vasopressin antagonist Manning compound (0 ± 3 mmHg; n = 10). In addition, cNTS/A2 lesions enhanced hyperosmolality-induced water intake (10.5 ± 1.4, vs. sham: 7.7 ± 0.8 ml/60 min; n = 8-10), without changing renal responses to hyperosmolality. The results suggest that inhibitory mechanisms dependent on cNTS/A2 neurons reduce water intake and vasopressin-dependent pressor response to an acute increase in plasma osmolality.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.publisherThe American Physiological Society.-
dc.subjectBlood pressureen
dc.subjectC-fos expressionen
dc.titleCatecholaminergic neurons in the comissural region of the nucleus of the solitary tract modulate hyperosmolality-induced responsesen
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Federal de Goias-
dc.contributor.institutionUniversidade Federal de São Paulo-
dc.contributor.institutionUniversity of Malaya-
dc.description.affiliationDepartment of Pathology and Physiology, School of Dentistry, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil-
dc.description.affiliationDepartment of Physiological Sciences, Federal University of Goias, Goiania, Goias, Brazil-
dc.description.affiliationDepartment of Physiology, Escola Paulista de Medicina, Universidade Federal de São Paulo (USP), São Paulo, Brazil-
dc.description.affiliationHenry Welcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, United Kingdom-
dc.description.affiliationDepartment of Physiology, University of Malaya, Kuala Lumpur, Malaysia-
dc.description.affiliationUnespDepartment of Pathology and Physiology, School of Dentistry, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil-
dc.description.sponsorshipIdBBSRC: BB/J015415/1-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofAmerican Journal Of Physiology. Regulatory, Integrative And Comparative Physiology-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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