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dc.contributor.authorAndrade, Dennia Perez de-
dc.contributor.authorVasconcellos, Luana Marotta Reis de-
dc.contributor.authorCarvalho, Isabel Chaves Silva-
dc.contributor.authorForte, Lilibeth Ferraz de Brito Penna-
dc.contributor.authorSouza Santos, Evelyn Luzia de-
dc.contributor.authorPrado, Renata Falchete do-
dc.contributor.authorSantos, Dalcy Roberto dos-
dc.contributor.authorCairo, Carlos Alberto Alves-
dc.contributor.authorCarvalho, Yasmin Rodarte-
dc.identifier.citationMaterials Science & Engineering. C, Materials For Biological Applications, v. 56, p. 538-544, 2015.-
dc.description.abstractResearch on new titanium alloys and different surface topographies aims to improve osseointegration. The objective of this study is to analyze the behavior of osteogenic cells cultivated on porous and dense samples of titanium-niobium alloys, and to compare them with the behavior of such type of cells on commercial pure titanium. Samples prepared using powder metallurgy were characterized using scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), X-ray diffraction (XRD), and metallographic and profilometer analyses. Osteogenic cells from newborn rat calvaria were plated over different groups: dense or porous samples composed of Ti or Ti-35niobium (Nb). Cell adhesion, cell proliferation, MTT assay, cell morphology, protein total content, alkaline phosphatase activity, and mineralization nodules were assessed. Results from XRD and EDS analysis confirmed the presence of Ti and Nb in the test alloy. Metallographic analysis revealed interconnected pores, with pore size ranging from 138 to 150μm. The profilometer analysis detected the greatest rugosity within the dense alloy samples. In vitro tests revealed similar biocompatibility between Ti-35Nb and Ti; furthermore, it was possible to verify that the association of porous surface topography and the Ti-35Nb alloy positively influenced mineralized matrix formation. We propose that the Ti-35Nb alloy with porous topography constitutes a biocompatible material with great potential for use in biomedical implants.en
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.publisherElsevier B. V.-
dc.subjectPorous surfacesen
dc.subjectTitanium niobium alloyen
dc.titleTitanium-35niobium alloy as a potential material for biomedical implants: in vitro studyen
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionAir and Space Institute (CTA)-
dc.description.affiliationDivision of Materials, Air and Space Institute, CTA, Praça Mal. do Ar Eduardo Gomes, 14, São José dos Campos 12904-000, SP, Brazil-
dc.description.affiliationUnespDepartment of Bioscience and Oral Diagnosis, Institute of Science and Technology, UNESP — Univ Estadual Paulista, State University of São Paulo (UNESP), Av. Engenheiro Francisco José Longo, 777, São José dos Campos 12245-000, SP, Brazil-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofMaterials Science & Engineering. C, Materials For Biological Applications-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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