You are in the accessibility menu

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/13179
Full metadata record
DC FieldValueLanguage
dc.contributor.authorTrindade, Cleide E. P.-
dc.contributor.authorBarreiros, Rodrigo C.-
dc.contributor.authorKurokawa, Cilmery Suemi-
dc.contributor.authorBossolan, Grasiela-
dc.date.accessioned2014-05-20T13:38:01Z-
dc.date.accessioned2016-10-25T16:54:25Z-
dc.date.available2014-05-20T13:38:01Z-
dc.date.available2016-10-25T16:54:25Z-
dc.date.issued2011-03-01-
dc.identifierhttp://dx.doi.org/10.1016/j.earlhumdev.2010.12.005-
dc.identifier.citationEarly Human Development. Clare: Elsevier B.V., v. 87, n. 3, p. 193-197, 2011.-
dc.identifier.issn0378-3782-
dc.identifier.urihttp://hdl.handle.net/11449/13179-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/13179-
dc.description.abstractBackground: Studies have suggested that different non-glucose sugars and sugar alcohols play a role in placental and fetal metabolism. However, the role of fructose in the fetal and newborn metabolism is unclear and studies are scarce.Aim: Our objective was to investigate the presence of fructose in umbilical cord blood in full-term gestation and its relationship with maternal and 48-hour-old- newborn blood concentrations, to evaluate fructose production by the fetus and newborn infant.Methods: Blood fructose and glucose concentrations were determined by HPLC in 26 paired samples of maternal blood, umbilical cord vein, and peripheral newborn blood at 48 h after birth. ANOVA, the Friedman Analysis of variance on Ranks and the Pearson correlation with p<0.05 were used.Results: Fructose concentration in umbilical cord blood was higher than maternal blood (p = 0.024), suggesting endogenous fructose production by the fetal-placental unit via the sorbitol pathway. Fructose concentrations were higher in newborns at 48 h after birth than in the fetal umbilical cord blood (p = 0.004), suggesting that fructose production is a continuous process from fetus to newborn.Conclusions: Fructose production by the sorbitol pathway, present in the fetus and newborn, is an alternative pathway in glucose metabolism probably used to maintain redox balance in the fetus. We suggest that endogenous fructose, similar to dietary ingested fructose, under physiological conditions produces the backbone for triacylglycerol and lipid synthesis in the fetus and newborn. Therefore the route for metabolizing fructose is already present in the early steps of human development. (C) 2010 Elsevier B.V. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.format.extent193-197-
dc.language.isoeng-
dc.publisherElsevier B.V.-
dc.sourceWeb of Science-
dc.subjectNewborn fructose metabolismen
dc.subjectFetus fructose metabolismen
dc.subjectFructoseen
dc.titleFructose in fetal cord blood and its relationship with maternal and 48-hour-newborn blood concentrationsen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionPontifícia Universidade Católica de São Paulo (PUC-SP)-
dc.description.affiliationSão Paulo State Univ, UNESP, Botucatu Sch Med, Dept Pediat,Div Neonatol, BR-18618970 São Paulo, Brazil-
dc.description.affiliationPUCSP Sorocaba, Sch Med, Dept Med Pediat, BR-18030095 São Paulo, Brazil-
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Botucatu Sch Med, Dept Pediat,Div Neonatol, BR-18618970 São Paulo, Brazil-
dc.description.sponsorshipIdFAPESP: 95/06906-1-
dc.description.sponsorshipIdFAPESP: 95/05169-3-
dc.identifier.doi10.1016/j.earlhumdev.2010.12.005-
dc.identifier.wosWOS:000293115900007-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofEarly Human Development-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.
 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.