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dc.contributor.authorNunes dos Santos, Amelia Miyashiro-
dc.contributor.authorGuinsburg, Ruth-
dc.contributor.authorBranco de Almeida, Maria Fernanda-
dc.contributor.authorProcianoy, Renato S.-
dc.contributor.authorLeone, Clea Rodrigues-
dc.contributor.authorMartins Marba, Sergio Tadeu-
dc.contributor.authorRugolo, Ligia Maria Suppo de Souza-
dc.contributor.authorFiori, Humberto Holmer-
dc.contributor.authorde Andrade Lopes, Jose Maria-
dc.contributor.authorMartinez, Francisco Eulogio-
dc.date.accessioned2014-05-20T13:38:01Z-
dc.date.accessioned2016-10-25T16:54:25Z-
dc.date.available2014-05-20T13:38:01Z-
dc.date.available2016-10-25T16:54:25Z-
dc.date.issued2011-09-01-
dc.identifierhttp://dx.doi.org/10.1016/j.jpeds.2011.02.040-
dc.identifier.citationJournal of Pediatrics. New York: Mosby-elsevier, v. 159, n. 3, p. 371-U220, 2011.-
dc.identifier.issn0022-3476-
dc.identifier.urihttp://hdl.handle.net/11449/13183-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/13183-
dc.description.abstractObjective To test the hypothesis that red blood cell (RBC) transfusions in preterm infants are associated with increased intra-hospital mortality.Study design Variables associated with death were studied with Cox regression analysis in a prospective cohort of preterm infants with birth weight <1500 g in the Brazilian Network on Neonatal Research. Intra-hospital death and death after 28 days of life were analyzed as dependent variables. Independent variables were infant demographic and clinical characteristics and RBC transfusions.Results of 1077 infants, 574 (53.3%) received at least one RBC transfusion during the hospital stay. The mean number of transfusions per infant was 3.3 +/- 3.4, with 2.1 +/- 2.1 in the first 28 days of life. Intra-hospital death occurred in 299 neonates (27.8%), and 60 infants (5.6%) died after 28 days of life. After adjusting for confounders, the relative risk of death during hospital stay was 1.49 in infants who received at least one RBC transfusion in the first 28 days of life, compared with infants who did not receive a transfusion. The risk of death after 28 days of life was 1.89 times higher in infants who received more than two RBC transfusions during their hospital stay, compared with infants who received one or two transfusions.Conclusion Transfusion was associated with increased death, and transfusion guidelines should consider risks and benefits of transfusion. (J Pediatr 2011; 159: 371-6).en
dc.format.extent371-U220-
dc.language.isoeng-
dc.publisherMosby-elsevier-
dc.sourceWeb of Science-
dc.titleRed Blood Cell Transfusions are Independently Associated with Intra-Hospital Mortality in Very Low Birth Weight Preterm Infantsen
dc.typeoutro-
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)-
dc.contributor.institutionUniversidade Federal do Rio Grande do Sul (UFRGS)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionPontificia Univ Catolica Rio Grande do Sul-
dc.contributor.institutionFundação Oswaldo Cruz-
dc.description.affiliationUniv Fed São Paulo, Dept Pediat, São Paulo, Brazil-
dc.description.affiliationUniversidade Federal do Rio Grande do Sul (UFRGS), Dept Pediat, Porto Alegre, RS, Brazil-
dc.description.affiliationUniv São Paulo, Dept Pediat, São Paulo, Brazil-
dc.description.affiliationUniv Estadual Campinas, Dept Pediat, Campinas, SP, Brazil-
dc.description.affiliationSão Paulo State Univ, Dept Pediat, Botucatu, SP, Brazil-
dc.description.affiliationPontificia Univ Catolica Rio Grande do Sul, Dept Pediat, Porto Alegre, RS, Brazil-
dc.description.affiliationFundação Oswaldo Cruz, Neonatal Dept, Fernandes Figueira Inst, Rio de Janeiro, Brazil-
dc.description.affiliationUniv São Paulo, Dept Pediat, BR-14049 Ribeirao Preto, Brazil-
dc.description.affiliationUnespSão Paulo State Univ, Dept Pediat, Botucatu, SP, Brazil-
dc.identifier.doi10.1016/j.jpeds.2011.02.040-
dc.identifier.wosWOS:000294054200006-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal of Pediatrics-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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