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http://acervodigital.unesp.br/handle/11449/13202
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DC Field | Value | Language |
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dc.contributor.author | Brunner, Hermine I. | - |
dc.contributor.author | Mina, Rina | - |
dc.contributor.author | Pilkington, Clarissa | - |
dc.contributor.author | Beresford, Michael W. | - |
dc.contributor.author | Reiff, Andreas | - |
dc.contributor.author | Levy, Deborah M. | - |
dc.contributor.author | Tucker, Lori B. | - |
dc.contributor.author | Eberhard, B. Anne | - |
dc.contributor.author | Ravelli, Angelo | - |
dc.contributor.author | Schanberg, Laura E. | - |
dc.contributor.author | Saad-Magalhaes, Claudia | - |
dc.contributor.author | Higgins, Gloria C. | - |
dc.contributor.author | Onel, Karen | - |
dc.contributor.author | Singer, Nora G. | - |
dc.contributor.author | von Scheven, Emily | - |
dc.contributor.author | Itert, Lukasz | - |
dc.contributor.author | Klein-Gitelman, Marisa S. | - |
dc.contributor.author | Punaro, Marilynn | - |
dc.contributor.author | Ying, Jun | - |
dc.contributor.author | Giannini, Edward H. | - |
dc.date.accessioned | 2014-05-20T13:38:03Z | - |
dc.date.accessioned | 2016-10-25T16:54:28Z | - |
dc.date.available | 2014-05-20T13:38:03Z | - |
dc.date.available | 2016-10-25T16:54:28Z | - |
dc.date.issued | 2011-09-01 | - |
dc.identifier | http://dx.doi.org/10.1002/acr.20507 | - |
dc.identifier.citation | Arthritis Care & Research. Malden: Wiley-blackwell, v. 63, n. 9, p. 1213-1223, 2011. | - |
dc.identifier.issn | 2151-464X | - |
dc.identifier.uri | http://hdl.handle.net/11449/13202 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/13202 | - |
dc.description.abstract | Objective. To develop widely acceptable preliminary criteria of global flare for childhood-onset systemic lupus erythematosus (cSLE).Methods. Pediatric rheumatologists (n = 138) rated a total of 358 unique patient profiles with information about the cSLE flare descriptors from 2 consecutive visits: patient global assessment of well-being, physician global assessment of disease activity (MD-global), health-related quality of life, anti-double-stranded DNA antibodies, disease activity index scores, protein: creatinine (P:C) ratio, complement levels, and erythrocyte sedimentation rate (ESR). Based on 2,996 rater responses about the course of cSLE (baseline versus followup), the accuracy (sensitivity, specificity, and area under the receiver operating characteristic curve) of candidate flare criteria was assessed. An international consensus conference was held to rank these candidate flare criteria as per the American College of Rheumatology recommendations for the development and validation of criteria sets.Results. The highest-ranked candidate criteria considered absolute changes (Delta) of the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) or British Isles Lupus Assessment Group (BILAG), MD-global, P:C ratio, and ESR; flare scores can be calculated (0.5 x Delta SLEDAI + 0.45 x Delta P:C ratio + 0.5 x Delta MD-global + 0.02 x Delta ESR), where values of >= 1.04 are reflective of a flare. Similarly, BILAG-based flare scores (0.4 x Delta BILAG + Delta 0.65 x Delta P:C ratio + 0.5 + Delta MD-global + 0.02 x Delta ESR) of >= 1.15 were diagnostic of a flare. Flare scores increased with flare severity.Conclusion. Consensus has been reached on preliminary criteria for global flares in cSLE. Further validation studies are needed to confirm the usefulness of the cSLE flare criteria in research and for clinical care. | en |
dc.description.sponsorship | NIH | - |
dc.description.sponsorship | National Institute of Arthritis and Musculoskeletal and Skin Diseases | - |
dc.format.extent | 1213-1223 | - |
dc.language.iso | eng | - |
dc.publisher | Wiley-Blackwell | - |
dc.source | Web of Science | - |
dc.title | Preliminary Criteria for Global Flares in Childhood-Onset Systemic Lupus Erythematosus | en |
dc.type | outro | - |
dc.contributor.institution | Univ Cincinnati | - |
dc.contributor.institution | Great Ormond St Hosp Sick Children | - |
dc.contributor.institution | Univ Coll Hosp | - |
dc.contributor.institution | Univ Liverpool | - |
dc.contributor.institution | Childrens Hosp Los Angeles | - |
dc.contributor.institution | Hosp Sick Children | - |
dc.contributor.institution | British Columbia Childrens Hosp | - |
dc.contributor.institution | Steven & Alexandra Cohen Childrens Med Ctr New Yo | - |
dc.contributor.institution | Univ Genoa | - |
dc.contributor.institution | Duke Univ | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Nationwide Childrens Hosp | - |
dc.contributor.institution | Ohio State Univ | - |
dc.contributor.institution | Univ Chicago | - |
dc.contributor.institution | Case Western Reserve Univ | - |
dc.contributor.institution | Metrohlth Med Ctr | - |
dc.contributor.institution | Univ Calif San Francisco | - |
dc.contributor.institution | Childrens Mem Hosp | - |
dc.contributor.institution | Texas Scottish Rite Hosp Crippled Children | - |
dc.description.affiliation | Univ Cincinnati, Cincinnati Childrens Hosp, Med Ctr, William S Rowe Div Rheumatol, Cincinnati, OH 45229 USA | - |
dc.description.affiliation | Great Ormond St Hosp Sick Children, London, England | - |
dc.description.affiliation | Univ Coll Hosp, London, England | - |
dc.description.affiliation | Univ Liverpool, Alder Hey Childrens Natl Hlth Serv Fdn Trust, Liverpool L69 3BX, Merseyside, England | - |
dc.description.affiliation | Childrens Hosp Los Angeles, Los Angeles, CA 90027 USA | - |
dc.description.affiliation | Hosp Sick Children, Toronto, on M5G 1X8, Canada | - |
dc.description.affiliation | British Columbia Childrens Hosp, Vancouver, BC V6H 3V4, Canada | - |
dc.description.affiliation | Steven & Alexandra Cohen Childrens Med Ctr New Yo, New York, NY USA | - |
dc.description.affiliation | Univ Genoa, Ist Giannina Gaslini, Genoa, Italy | - |
dc.description.affiliation | Duke Univ, Med Ctr, Durham, NC USA | - |
dc.description.affiliation | Univ Estadual Paulista, São Paulo, Brazil | - |
dc.description.affiliation | Nationwide Childrens Hosp, Columbus, OH USA | - |
dc.description.affiliation | Ohio State Univ, Columbus, OH 43210 USA | - |
dc.description.affiliation | Univ Chicago, Comer Childrens Hosp, Chicago, IL 60637 USA | - |
dc.description.affiliation | Case Western Reserve Univ, Cleveland, OH 44106 USA | - |
dc.description.affiliation | Metrohlth Med Ctr, Cleveland, OH USA | - |
dc.description.affiliation | Univ Calif San Francisco, San Francisco, CA 94143 USA | - |
dc.description.affiliation | Childrens Mem Hosp, Chicago, IL 60614 USA | - |
dc.description.affiliation | Texas Scottish Rite Hosp Crippled Children, Dallas, TX USA | - |
dc.description.affiliation | Univ Cincinnati, Cincinnati, OH USA | - |
dc.description.affiliationUnesp | Univ Estadual Paulista, São Paulo, Brazil | - |
dc.description.sponsorshipId | NIH: 5U01-AR51868 | - |
dc.description.sponsorshipId | NIH: P30-AR AR47363 | - |
dc.description.sponsorshipId | NIH: P60-AR047884 | - |
dc.description.sponsorshipId | NIH: 2UL1RR026314 | - |
dc.description.sponsorshipId | National Institute of Arthritis and Musculoskeletal and Skin Diseases: T32100291 | - |
dc.description.sponsorshipId | National Institute of Arthritis and Musculoskeletal and Skin Diseases: K23AR053202 | - |
dc.identifier.doi | 10.1002/acr.20507 | - |
dc.identifier.wos | WOS:000295254900001 | - |
dc.rights.accessRights | Acesso aberto | - |
dc.relation.ispartof | Arthritis Care & Research | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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