You are in the accessibility menu

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/13205
Full metadata record
DC FieldValueLanguage
dc.contributor.authorParodi, Alessandro-
dc.contributor.authorDavi, Sergio-
dc.contributor.authorBeatriz Pringe, Alejandra-
dc.contributor.authorPistorio, Angela-
dc.contributor.authorRuperto, Nicolino-
dc.contributor.authorMagni-Manzoni, Silvia-
dc.contributor.authorMiettunen, Paivi-
dc.contributor.authorBader-Meunier, Brigitte-
dc.contributor.authorEspada, Graciela-
dc.contributor.authorSterba, Gary-
dc.contributor.authorOzen, Seza-
dc.contributor.authorWright, Dowain-
dc.contributor.authorMagalhães, Cláudia Saad-
dc.contributor.authorKhubchandani, Raju-
dc.contributor.authorMichels, Hartmut-
dc.contributor.authorWoo, Patricia-
dc.contributor.authorIglesias, Antonio-
dc.contributor.authorGuseinova, Dinara-
dc.contributor.authorBracaglia, Claudia-
dc.contributor.authorHayward, Kristen-
dc.contributor.authorWouters, Carine-
dc.contributor.authorGrom, Alexei-
dc.contributor.authorVivarelli, Marina-
dc.contributor.authorFischer, Alberto-
dc.contributor.authorBreda, Luciana-
dc.contributor.authorMartini, Alberto-
dc.contributor.authorRavelli, Angelo-
dc.date.accessioned2014-05-20T13:38:04Z-
dc.date.accessioned2016-10-25T16:54:28Z-
dc.date.available2014-05-20T13:38:04Z-
dc.date.available2016-10-25T16:54:28Z-
dc.date.issued2009-11-01-
dc.identifierhttp://dx.doi.org/10.1002/art.24883-
dc.identifier.citationArthritis and Rheumatism. Hoboken: Wiley-liss, v. 60, n. 11, p. 3388-3399, 2009.-
dc.identifier.issn0004-3591-
dc.identifier.urihttp://hdl.handle.net/11449/13205-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/13205-
dc.description.abstractObjective. To describe the clinical and laboratory features of macrophage activation syndrome as a complication of juvenile systemic lupus erythematosus (SLE).Methods. Cases of juvenile SLE-associated macrophage activation syndrome were provided by investigators belonging to 3 pediatric rheumatology networks or were found in the literature. Patients who had evidence of macrophage hemophagocytosis on bone marrow aspiration were considered to have definite macrophage activation syndrome, and those who did not have such evidence were considered to have probable macrophage activation syndrome. Clinical and laboratory findings in patients with macrophage activation syndrome were contrasted with those of 2 control groups composed of patients with active juvenile SLE without macrophage activation syndrome. The ability of each feature to discriminate macrophage activation syndrome from active disease was evaluated by calculating sensitivity, specificity, and area under the receiver operating characteristic curve.Results. The study included 38 patients (20 with definite macrophage activation syndrome and 18 with probable macrophage activation syndrome). Patients with definite and probable macrophage activation syndrome were comparable with regard to all clinical and laboratory features of the syndrome, except for a greater frequency of lymphadenopathy, leukopenia, and thrombocytopenia in patients with definite macrophage activation syndrome. Overall, clinical features had better specificity than sensitivity, except for fever, which was highly sensitive but had low specificity. Among laboratory features, the best sensitivity and specificity was achieved using hyperferritinemia, followed by increased levels of lactate dehydrogenase, hypertriglyceridemia, and hypofibrinogenemia. Based on the results of statistical analysis, preliminary diagnostic guidelines for macrophage activation syndrome in juvenile SLE were developed.Conclusion. Our findings indicate that the occurrence of unexplained fever and cytopenia, when associated with hyperferritinemia, in a patient with juvenile SLE should raise the suspicion of macrophage activation syndrome. We propose preliminary guidelines for this syndrome in juvenile SLE to facilitate timely diagnosis and correct classification of patients.en
dc.description.sponsorshipEuropean Union-
dc.format.extent3388-3399-
dc.language.isoeng-
dc.publisherWiley-liss-
dc.sourceWeb of Science-
dc.titleMacrophage Activation Syndrome in Juvenile Systemic Lupus Erythematosus A Multinational Multicenter Study of Thirty-Eight Patientsen
dc.typeoutro-
dc.contributor.institutionIst Ricovero & Cura Carattere Sci G Gaslini-
dc.contributor.institutionHosp Gen Ninos Pedro Elizalde-
dc.contributor.institutionPoliclin San Matteo-
dc.contributor.institutionAlberta Childrens Prov Gen Hosp-
dc.contributor.institutionHop Necker Enfants Malad-
dc.contributor.institutionHosp Ninos Dr Ricardo Gutierrez-
dc.contributor.institutionHosp Clin Caracas-
dc.contributor.institutionHacettepe Univ-
dc.contributor.institutionChildrens Hosp Cent Calif-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionJaslok Hosp & Res Ctr-
dc.contributor.institutionGerman Ctr Pediat Rheumatol-
dc.contributor.institutionGreat Ormond St Hosp Sick Children-
dc.contributor.institutionUniv Nacl Colombia-
dc.contributor.institutionUniv Hosp-
dc.contributor.institutionOsped Pediat Bambino Gesu-
dc.contributor.institutionSeattle Childrens Hosp-
dc.contributor.institutionUniv Hosp Gasthuisberg-
dc.contributor.institutionCincinnati Childrens Hosp-
dc.contributor.institutionOsped Acireale CT-
dc.contributor.institutionUniv G dAnnunzio-
dc.contributor.institutionUniv Genoa-
dc.description.affiliationIst Ricovero & Cura Carattere Sci G Gaslini, Genoa, Italy-
dc.description.affiliationHosp Gen Ninos Pedro Elizalde, Buenos Aires, DF, Argentina-
dc.description.affiliationPoliclin San Matteo, IRCCS Fdn, I-27100 Pavia, Italy-
dc.description.affiliationAlberta Childrens Prov Gen Hosp, Calgary, AB T2T 5C7, Canada-
dc.description.affiliationHop Necker Enfants Malad, Assistance Publ Hop Paris, Paris, France-
dc.description.affiliationHosp Ninos Dr Ricardo Gutierrez, Buenos Aires, DF, Argentina-
dc.description.affiliationHosp Clin Caracas, Caracas, Venezuela-
dc.description.affiliationHacettepe Univ, Childrens Hosp, Ankara, Turkey-
dc.description.affiliationChildrens Hosp Cent Calif, Madera, CA USA-
dc.description.affiliationUNESP, Fac Med Botucatu, Hosp Clin, Botucatu, SP, Brazil-
dc.description.affiliationJaslok Hosp & Res Ctr, Bombay, Maharashtra, India-
dc.description.affiliationGerman Ctr Pediat Rheumatol, Garmisch Partenkirchen, Germany-
dc.description.affiliationGreat Ormond St Hosp Sick Children, London WC1N 3JH, England-
dc.description.affiliationUniv Nacl Colombia, Bogota, Colombia-
dc.description.affiliationUniv Hosp, Childrens Clin, Riga, Latvia-
dc.description.affiliationOsped Pediat Bambino Gesu, Rome, Italy-
dc.description.affiliationSeattle Childrens Hosp, Seattle, WA USA-
dc.description.affiliationUniv Hosp Gasthuisberg, B-3000 Louvain, Belgium-
dc.description.affiliationCincinnati Childrens Hosp, Med Ctr, Cincinnati, OH USA-
dc.description.affiliationOsped Acireale CT, UO Pediat, Acireale, Italy-
dc.description.affiliationUniv G dAnnunzio, Chieti, Italy-
dc.description.affiliationUniv Genoa, Genoa, Italy-
dc.description.affiliationUnespUNESP, Fac Med Botucatu, Hosp Clin, Botucatu, SP, Brazil-
dc.description.sponsorshipIdEU: AML/B7-311/970666/II-0246-FI-
dc.identifier.doi10.1002/art.24883-
dc.identifier.wosWOS:000271781400028-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofArthritis and Rheumatism-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.
 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.