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dc.contributor.authorGarcia, Juliana Albarracin-
dc.contributor.authorFerreira, Helena Lage-
dc.contributor.authorVieira, Flavia Volpato-
dc.contributor.authorGameiro, Roberto-
dc.contributor.authorAndrade, Alexandre Lima de-
dc.contributor.authorEugenio, Flavia de Rezende-
dc.contributor.authorFlores, Eduardo Furtado-
dc.contributor.authorCardoso, Tereza Cristina-
dc.identifier.citationVeterinary and Comparative Oncology, p. 1-9, 2015.-
dc.description.abstractOncolytic virotherapy is a novel strategy for treatment of cancer in humans and companion animals as well. Canine distemper virus (CDV), a paramyxovirus, has proven to be oncolytic through induction of apoptosis in canine-derived tumour cells, yet the mechanism behind this inhibitory action is poorly understood. In this study, three human mammary tumour cell lines and one canine-derived adenofibrosarcoma cell line were tested regarding to their susceptibility to CDV infection, cell proliferation, apoptosis, mitochondrial membrane potential and expression of tumour necrosis factor-alpha-induced protein 8 (TNFAIP8). CDV replication-induced cytopathic effect, decrease of cell proliferation rates, and >45% of infected cells were considered death and/or under late apoptosis/necrosis. TNFAIP8 and CDVM gene expression were positively correlated in all cell lines. In addition, mitochondrial membrane depolarization was associated with increase in virus titres (p < 0.005). Thus, these results strongly suggest that both human and canine mammary tumour cells are potential candidates for studies concerning CDV-induced cancer therapy.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.sourceCurrículo Lattes-
dc.subjectCancer markersen
dc.subjectCanine and human mammary tumoursen
dc.subjectCell phenotypeen
dc.subjectIn vitro cultureen
dc.titleTumour necrosis factor-alpha-induced protein 8 (TNFAIP8) expression associated with cell survival and death in cancer cell lines infected with canine distemper virusen
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Federal de Santa Maria (UFSM)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Medicicna Veterinária de Araçatuba, Araçatuba, Rua Clóvis Pestana 739, Dona amélia, CEP 16050680, SP, Brasil-
dc.description.affiliationFZEA-USP, Department of de Veterinary Medicine, Pirassununga, São Paulo, Brazil-
dc.description.affiliationDepartment of Preventive Veterinary Medicine, Federal University of Santa Maria, Santa Maria, RS, Brazil-
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Medicicna Veterinária de Araçatuba, Departamento de Clínica, Cirurgia e Reprodução Animal, Araçatuba, Rua Clóvis Pestana 739, Dona amélia, CEP-
dc.description.affiliationUnespDepartamento de Apoio, Produção e Saúde Animal 16050680, SP, Brasil-
dc.description.sponsorshipIdFAPESP: 2010/52465-9-
dc.description.sponsorshipIdFAPESP: 2011/50845-1-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofVeterinary and Comparative Oncology-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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