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http://acervodigital.unesp.br/handle/11449/133112
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DC Field | Value | Language |
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dc.contributor.author | Garcia, Juliana Albarracin | - |
dc.contributor.author | Ferreira, Helena Lage | - |
dc.contributor.author | Vieira, Flavia Volpato | - |
dc.contributor.author | Gameiro, Roberto | - |
dc.contributor.author | Andrade, Alexandre Lima de | - |
dc.contributor.author | Eugenio, Flavia de Rezende | - |
dc.contributor.author | Flores, Eduardo Furtado | - |
dc.contributor.author | Cardoso, Tereza Cristina | - |
dc.date.accessioned | 2016-01-28T16:53:41Z | - |
dc.date.accessioned | 2016-10-25T21:27:18Z | - |
dc.date.available | 2016-01-28T16:53:41Z | - |
dc.date.available | 2016-10-25T21:27:18Z | - |
dc.date.issued | 2015 | - |
dc.identifier | http://dx.doi.org/10.1111/vco.12168 | - |
dc.identifier.citation | Veterinary and Comparative Oncology, p. 1-9, 2015. | - |
dc.identifier.issn | 1476-5829 | - |
dc.identifier.uri | http://hdl.handle.net/11449/133112 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/133112 | - |
dc.description.abstract | Oncolytic virotherapy is a novel strategy for treatment of cancer in humans and companion animals as well. Canine distemper virus (CDV), a paramyxovirus, has proven to be oncolytic through induction of apoptosis in canine-derived tumour cells, yet the mechanism behind this inhibitory action is poorly understood. In this study, three human mammary tumour cell lines and one canine-derived adenofibrosarcoma cell line were tested regarding to their susceptibility to CDV infection, cell proliferation, apoptosis, mitochondrial membrane potential and expression of tumour necrosis factor-alpha-induced protein 8 (TNFAIP8). CDV replication-induced cytopathic effect, decrease of cell proliferation rates, and >45% of infected cells were considered death and/or under late apoptosis/necrosis. TNFAIP8 and CDVM gene expression were positively correlated in all cell lines. In addition, mitochondrial membrane depolarization was associated with increase in virus titres (p < 0.005). Thus, these results strongly suggest that both human and canine mammary tumour cells are potential candidates for studies concerning CDV-induced cancer therapy. | en |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | - |
dc.format.extent | 1-9 | - |
dc.language.iso | eng | - |
dc.source | Currículo Lattes | - |
dc.subject | Cancer markers | en |
dc.subject | Canine and human mammary tumours | en |
dc.subject | Cell phenotype | en |
dc.subject | In vitro culture | en |
dc.title | Tumour necrosis factor-alpha-induced protein 8 (TNFAIP8) expression associated with cell survival and death in cancer cell lines infected with canine distemper virus | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Universidade Federal de Santa Maria (UFSM) | - |
dc.contributor.institution | Universidade de São Paulo (USP) | - |
dc.description.affiliation | Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Medicicna Veterinária de Araçatuba, Araçatuba, Rua Clóvis Pestana 739, Dona amélia, CEP 16050680, SP, Brasil | - |
dc.description.affiliation | FZEA-USP, Department of de Veterinary Medicine, Pirassununga, São Paulo, Brazil | - |
dc.description.affiliation | Department of Preventive Veterinary Medicine, Federal University of Santa Maria, Santa Maria, RS, Brazil | - |
dc.description.affiliationUnesp | Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Medicicna Veterinária de Araçatuba, Departamento de Clínica, Cirurgia e Reprodução Animal, Araçatuba, Rua Clóvis Pestana 739, Dona amélia, CEP | - |
dc.description.affiliationUnesp | Departamento de Apoio, Produção e Saúde Animal 16050680, SP, Brasil | - |
dc.description.sponsorshipId | FAPESP: 2010/52465-9 | - |
dc.description.sponsorshipId | FAPESP: 2011/50845-1 | - |
dc.identifier.doi | 10.1111/vco.12168 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Veterinary and Comparative Oncology | - |
dc.identifier.lattes | 4272904699684196 | - |
dc.identifier.lattes | 5359531229053723 | - |
dc.identifier.lattes | 5431798684243196 | - |
dc.identifier.lattes | 6404176495306171 | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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