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dc.contributor.authorGarcia, Valdir Gouveia-
dc.contributor.authorFernades, Leandro Araújo-
dc.contributor.authorMacarini, Valmir Campos-
dc.contributor.authorAlmeida, Juliano Milanezi de-
dc.contributor.authorMartins, Thiago Marchi-
dc.contributor.authorBosco, Alvaro Francisco-
dc.contributor.authorNagata, Maria Jose Hitomi-
dc.contributor.authorCirelli, Joni Augusto-
dc.contributor.authorTheodoro, Letícia Helena-
dc.identifier.citationJournal of Clinical Periodontology, v. 38, p. 1106-1114, 2011.-
dc.description.abstractBackground The aim of this study was to compare antimicrobial photodynamic therapy (aPDT) as an adjunctive treatment to scaling and root planing (SRP) for induced periodontitis in nicotine-modified rats. Material & Methods A total of 240 rats were evenly divided into two groups: C – saline solution treatment; N – nicotine treatment. Periodontal disease was induced in both groups at the first mandibular molar. After 7 days, the ligature was removed. All animals were submitted to SRP and were divided according to the following treatments: SRP – irrigation with saline solution; Toluidine Blue-O (TBO) – irrigation with phenothiazinium dye (100 μg/ml); LLLT – laser irradiation (660 nm; 0.03 W; 4 J); and aPDT – TBO and laser irradiation. Ten animals in each group/treatment were euthanized at 7, 15 and 30 days. The histometric and immunohistochemical values were statistically analysed. Results Intragroup analysis demonstrated that in both groups the aPDT treatment resulted in lower bone loss (BL) when compared to SRP in all experimental periods. Intergroup analysis demonstrated that aPDT treatment resulted in lower BL in Group N than in Group C treated with SRP in all experimental periods. Conclusion Antimicrobial photodynamic therapy was an effective adjunctive treatment to SRP for induced periodontitis in nicotine-modified rats.en
dc.sourceCurrículo Lattes-
dc.subjectAlveolar bone lossen
dc.titleTreatment of experimental periodontal disease by antimicrobial photodynamic therapy in nicotine-modified ratsen
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Federal de Alfenas (UNIFAL)-
dc.contributor.institutionCentro Universitário da Fundação Educacional de Barretos (UNIFEB)-
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Odontologia de Araçatuba, Aracatuba, Rua Jose Bonifacio 1193, Vila Mendonça, CEP 16015-050, SP, Brasil-
dc.description.affiliationDepartmentof Clinic and Surgery, Federal University ofAlfenas, Alfenas, MG, Brazil;3Mastercourse, University Center of the EducationalFoundation of Barretos (UNIFEB), DentalSchool of Barretos, Barretos, SP, Brazil-
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Odontologia de Araçatuba, Araçatuba, Rua José Bonifacio 1193, Vila Mendonça, CEP 16015-050, SP, Brasil-
dc.description.affiliationUnespDepartment of Diagnosis and Surgery,Division of Periodontics, São Paulo StateUniversity, Araraquara, São Paulo, Brazil-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal of Clinical Periodontology-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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